Animal and human studies on developmental monaural hearing loss

Karen Gordon, Andrej Kral

Research output: Contribution to journalReview articleResearchpeer-review

Abstract

Asymmetric hearing has been the focus of many studies on brain plasticity in the past. Recently, the topic has gained clinical importance in cases with sequential cochlear implantation or in cases with deafness in one ear and preserved hearing in the other ear. Convergent evidence from animal experiments and from hearing impaired children suggest that asymmetric hearing during early development can reorganize the central auditory representation of the two ears with the consequence of a “stronger” representation of the better hearing ear with a “weaker” representation of the other, more poorly hearing, ear. These changes lead to a persistent aural preference for one ear, demonstrated by asymmetric speech comprehension when each ear is tested separately. Further, binaural integration is compromised as shown by reduced binaural fusion and reduced sensitivity for binaural cues. Finally, the data demonstrate a significant difference in cortical plasticity in response to juvenile monocular deprivation in the visual system and juvenile monaural deafness in the auditory system. The topic represents a unique example of translational research whereby mechanisms explored in animal models are combined with data from children to understand the clinical consequences of asymmetric hearing in early development.

LanguageEnglish
Pages60-74
Number of pages15
JournalHearing Research
Volume380
DOIs
Publication statusPublished - 1 Sep 2019

Fingerprint

Hearing Loss
Ear
Hearing
Deafness
Cochlear Implantation
Translational Medical Research
Cues
Animal Models
Brain

Bibliographical note

Copyright the Author(s) 2019. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • Cochlear implant
  • Deprivation
  • Plasticity
  • Single-sided deafness
  • Unilateral hearing loss

Cite this

Gordon, Karen ; Kral, Andrej. / Animal and human studies on developmental monaural hearing loss. In: Hearing Research. 2019 ; Vol. 380. pp. 60-74.
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Animal and human studies on developmental monaural hearing loss. / Gordon, Karen; Kral, Andrej.

In: Hearing Research, Vol. 380, 01.09.2019, p. 60-74.

Research output: Contribution to journalReview articleResearchpeer-review

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