Animal models of Alzheimer's disease and frontotemporal dementia

Jürgen Götz*, Lars M. Ittner

*Corresponding author for this work

Research output: Contribution to journalReview article

517 Citations (Scopus)

Abstract

Insoluble protein aggregates have been linked to Alzheimer's disease (AD) and frontotemporal dementia (FTD). Recent work in transgenic mice has shed light on the role of these aggregates by identifying soluble oligomeric species that may interfere with essential cellular mechanisms at an early disease stage. This review summarizes what we have learned about the roles of these proteins from transgenic mice and invertebrate species such as flies and worms. Proteomic and transcriptomic analyses of tissue from these animal models have identified new molecules with crucial roles in disease. Moreover, transgenic animals have been instrumental in defining drug targets and designing novel therapeutic strategies. With advanced imaging techniques that can be used in both humans and mice an early, preclinical diagnosis of AD and FTD could be within reach.

Original languageEnglish
Pages (from-to)532-544
Number of pages13
JournalNature Reviews Neuroscience
Volume9
Issue number7
DOIs
Publication statusPublished - 1 Jan 2008
Externally publishedYes

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