Animal models reveal role for tau phosphorylation in human disease

Jürgen Götz*, Amadeus Gladbach, Luis Pennanen, Janet van Eersel, Andreas Schild, Della David, Lars M. Ittner

*Corresponding author for this work

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Many proteins that are implicated in human disease are posttranslationally modified. This includes the microtubule-associated protein tau that is deposited in a hyperphosphorylated form in brains of Alzheimer's disease patients. The focus of this review article is on the physiological and pathological phosphorylation of tau; the relevance of aberrant phosphorylation for disease; the role of kinases and phosphatases in this process; its modeling in transgenic mice, flies, and worms; and implications of phosphorylation for therapeutic intervention.

Original languageEnglish
Pages (from-to)860-871
Number of pages12
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1802
Issue number10
DOIs
Publication statusPublished - 1 Oct 2010
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Amyloid
  • Drosophila
  • Frontotemporal dementia
  • Kinase
  • Mice
  • Nematode
  • Phosphatase
  • Phosphorylation
  • Tau
  • Transgenic

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