Animal models reveal role for tau phosphorylation in human disease

Jürgen Götz; Amadeus Gladbach; Luis Pennanen; Janet van Eersel; Andreas Schild; Della David; Lars M. Ittner

doi:10.1016/j.bbadis.2009.09.008

Animal models reveal role for tau phosphorylation in human disease

Jürgen Götz^*, Amadeus Gladbach, Luis Pennanen, Janet van Eersel, Andreas Schild, Della David, Lars M. Ittner

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

72 Citations (Scopus)

Abstract

Many proteins that are implicated in human disease are posttranslationally modified. This includes the microtubule-associated protein tau that is deposited in a hyperphosphorylated form in brains of Alzheimer's disease patients. The focus of this review article is on the physiological and pathological phosphorylation of tau; the relevance of aberrant phosphorylation for disease; the role of kinases and phosphatases in this process; its modeling in transgenic mice, flies, and worms; and implications of phosphorylation for therapeutic intervention.

Original language	English
Pages (from-to)	860-871
Number of pages	12
Journal	Biochimica et Biophysica Acta - Molecular Basis of Disease
Volume	1802
Issue number	10
DOIs	https://doi.org/10.1016/j.bbadis.2009.09.008
Publication status	Published - 1 Oct 2010
Externally published	Yes

Keywords

Alzheimer's disease
Amyloid
Drosophila
Frontotemporal dementia
Kinase
Mice
Nematode
Phosphatase
Phosphorylation
Tau
Transgenic

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10.1016/j.bbadis.2009.09.008

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abstract = "Many proteins that are implicated in human disease are posttranslationally modified. This includes the microtubule-associated protein tau that is deposited in a hyperphosphorylated form in brains of Alzheimer's disease patients. The focus of this review article is on the physiological and pathological phosphorylation of tau; the relevance of aberrant phosphorylation for disease; the role of kinases and phosphatases in this process; its modeling in transgenic mice, flies, and worms; and implications of phosphorylation for therapeutic intervention.",

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AU - Götz, Jürgen

AU - Gladbach, Amadeus

AU - Pennanen, Luis

AU - van Eersel, Janet

AU - Schild, Andreas

AU - David, Della

AU - Ittner, Lars M.

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KW - Amyloid

KW - Drosophila

KW - Frontotemporal dementia

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KW - Nematode

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Animal models reveal role for tau phosphorylation in human disease

Abstract

Keywords

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