Annexin A1 expression in a pooled breast cancer series: Association with tumor subtypes and prognosis

Marcelo Sobral-Leite; Jelle Wesseling; Vincent T.H.B.M. Smit; Heli Nevanlinna; Martine H. van Miltenburg; Joyce Sanders; Ingrid Hofland; Fiona M. Blows; Penny Coulson; Gazinska Patrycja; Jan H.M. Schellens; Rainer Fagerholm; Päivi Heikkilä; Kristiina Aittomäki; Carl Blomqvist; Elena Provenzano; Hamid Raza Ali; Jonine Figueroa; Mark Sherman; Jolanta Lissowska; Arto Mannermaa; Vesa Kataja; Veli Matti Kosma; Jaana M. Hartikainen; Kelly Anne Phillips; Fergus J. Couch; Janet E. Olson; Celine Vachon; Daniel Visscher; Hermann Brenner; Katja Butterbach; Volker Arndt; Bernd Holleczek; Maartje J. Hooning; Antoinette Hollestelle; John W.M. Martens; Carolien H.M. van Deurzen; Bob van de Water; Annegien Broeks; Jenny Chang-Claude; Georgia Chenevix-Trench; Douglas F. Easton; Paul D.P. Pharoah; Montserrat García-Closas; Marjo de Graauw; Marjanka K. Schmidt; Morteza Aghmesheh; David Amor; Lesley Andrews; Yoland Antill; Shane Armitage; Leanne Arnold; Rosemary Balleine; Agnes Bankier; Patti Bastick; Jonathan Beesley; John Beilby; Barbara Bennett; Ian Bennett; Geoffrey Berry; Anneke Blackburn; Michael Bogwitz; Meagan Brennan; Melissa Brown; Michael Buckley; Matthew Burgess; Jo Burke; Phyllis Butow; Keith Byron; David Callen; Ian Campbell; Deepa Chauhan; Manisha Chauhan; Alice Christian; Christine Clarke; Alison Colley; Dick Cotton; Ashley Crook; James Cui; Bronwyn Culling; Margaret Cummings; Sarah Jane Dawson; Anna deFazio; Martin Delatycki; Rebecca Dickson; Joanne Dixon; Alexander Dobrovic; Tracy Dudding; Ted Edkins; Stacey Edwards; Maurice Eisenbruch; Gelareh Farshid; Susan Fawcett; Andrew Fellows; Georgina Fenton; Michael Field; Frank Firgaira; James Flanagan; Jean Fleming; Peter Fong; John Forbes; Stephen Fox; Juliet French; Michael Friedlander; Clara Gaff; Mac Gardner; Mike Gattas; Peter George; Graham Giles; Grantley Gill; Jack Goldblatt; Sian Greening; Scott Grist; Eric Haan; Kate Hardie; Marion Harris; Stewart Hart; Nick Hayward; Sue Healey; Louise Heiniger; John Hopper; Evelyn Humphrey; Clare Hunt; Paul James; Mark Jenkins; Alison Jones; Rick Kefford; Alexa Kidd; Belinda Kiely; Judy Kirk; Jessica Koehler; James Kollias; Serguei Kovalenko; Sunil Lakhani; Amanda Leaming; Jennifer Leary; Jacqueline Lim; Geoff Lindeman; Lara Lipton; Liz Lobb; Graham Mann; Deborah Marsh; Sue Anne McLachlan; Bettina Meiser; Cliff Meldrum; Roger Milne; Gillian Mitchell; Beth Newman; Eveline Niedermayr; Sophie Nightingale; Shona O'Connell; Imelda O'Loughlin; Richard Osborne; Nick Pachter; Briony Patterson; Lester Peters; Kelly Phillips; Melanie Price; Lynne Purser; Tony Reeve; Jeanne Reeve; Robert Richards; Edwina Rickard; Bridget Robinson; Barney Rudzki; Mona Saleh; Elizabeth Salisbury; Joe Sambrook; Christobel Saunders; Jodi Saunus; Robyn Sayer; Elizabeth Scott; Rodney Scott; Clare Scott; Ram Seshadri; Adrienne Sexton; Raghwa Sharma; Andrew Shelling; Peter Simpson; Melissa Southey; Amanda Spurdle; Graeme Suthers; Pamela Sykes; Margaret Tassell; Donna Taylor; Jessica Taylor; Benjamin Thierry; Susan Thomas; Ella Thompson; Heather Thorne; Sharron Townshend; Alison Trainer; Lan Tran; Kathy Tucker; Janet Tyler; Jane Visvader; Logan Walker; Ian Walpole; Robin Ward; Paul Waring; Bev Warner; Graham Warren; Rachael Williams; Judy Wilson; Ingrid Winship; Kathy Wu; Mary Ann Young; D. Bowtell; A. Green; P. Webb; A. de Fazio; D. Gertig; kConFab/AOCS Investigators

doi:10.1186/s12916-015-0392-6

Annexin A1 expression in a pooled breast cancer series: Association with tumor subtypes and prognosis

Marcelo Sobral-Leite, Jelle Wesseling, Vincent T.H.B.M. Smit, Heli Nevanlinna, Martine H. van Miltenburg, Joyce Sanders, Ingrid Hofland, Fiona M. Blows, Penny Coulson, Gazinska Patrycja, Jan H.M. Schellens, Rainer Fagerholm, Päivi Heikkilä, Kristiina Aittomäki, Carl Blomqvist, Elena Provenzano, Hamid Raza Ali, Jonine Figueroa, Mark Sherman, Jolanta LissowskaArto Mannermaa, Vesa Kataja, Veli Matti Kosma, Jaana M. Hartikainen, Kelly Anne Phillips, Fergus J. Couch, Janet E. Olson, Celine Vachon, Daniel Visscher, Hermann Brenner, Katja Butterbach, Volker Arndt, Bernd Holleczek, Maartje J. Hooning, Antoinette Hollestelle, John W.M. Martens, Carolien H.M. van Deurzen, Bob van de Water, Annegien Broeks, Jenny Chang-Claude, Georgia Chenevix-Trench, Douglas F. Easton, Paul D.P. Pharoah, Montserrat García-Closas, Marjo de Graauw, Marjanka K. Schmidt^*, Morteza Aghmesheh, David Amor, Lesley Andrews, Yoland Antill, Shane Armitage, Leanne Arnold, Rosemary Balleine, Agnes Bankier, Patti Bastick, Jonathan Beesley, John Beilby, Barbara Bennett, Ian Bennett, Geoffrey Berry, Anneke Blackburn, Michael Bogwitz, Meagan Brennan, Melissa Brown, Michael Buckley, Matthew Burgess, Jo Burke, Phyllis Butow, Keith Byron, David Callen, Ian Campbell, Deepa Chauhan, Manisha Chauhan, Alice Christian, Christine Clarke, Alison Colley, Dick Cotton, Ashley Crook, James Cui, Bronwyn Culling, Margaret Cummings, Sarah Jane Dawson, Anna deFazio, Martin Delatycki, Rebecca Dickson, Joanne Dixon, Alexander Dobrovic, Tracy Dudding, Ted Edkins, Stacey Edwards, Maurice Eisenbruch, Gelareh Farshid, Susan Fawcett, Andrew Fellows, Georgina Fenton, Michael Field, Frank Firgaira, James Flanagan, Jean Fleming, Peter Fong, John Forbes, Stephen Fox, Juliet French, Michael Friedlander, Clara Gaff, Mac Gardner, Mike Gattas, Peter George, Graham Giles, Grantley Gill, Jack Goldblatt, Sian Greening, Scott Grist, Eric Haan, Kate Hardie, Marion Harris, Stewart Hart, Nick Hayward, Sue Healey, Louise Heiniger, John Hopper, Evelyn Humphrey, Clare Hunt, Paul James, Mark Jenkins, Alison Jones, Rick Kefford, Alexa Kidd, Belinda Kiely, Judy Kirk, Jessica Koehler, James Kollias, Serguei Kovalenko, Sunil Lakhani, Amanda Leaming, Jennifer Leary, Jacqueline Lim, Geoff Lindeman, Lara Lipton, Liz Lobb, Graham Mann, Deborah Marsh, Sue Anne McLachlan, Bettina Meiser, Cliff Meldrum, Roger Milne, Gillian Mitchell, Beth Newman, Eveline Niedermayr, Sophie Nightingale, Shona O'Connell, Imelda O'Loughlin, Richard Osborne, Nick Pachter, Briony Patterson, Lester Peters, Kelly Phillips, Melanie Price, Lynne Purser, Tony Reeve, Jeanne Reeve, Robert Richards, Edwina Rickard, Bridget Robinson, Barney Rudzki, Mona Saleh, Elizabeth Salisbury, Joe Sambrook, Christobel Saunders, Jodi Saunus, Robyn Sayer, Elizabeth Scott, Rodney Scott, Clare Scott, Ram Seshadri, Adrienne Sexton, Raghwa Sharma, Andrew Shelling, Peter Simpson, Melissa Southey, Amanda Spurdle, Graeme Suthers, Pamela Sykes, Margaret Tassell, Donna Taylor, Jessica Taylor, Benjamin Thierry, Susan Thomas, Ella Thompson, Heather Thorne, Sharron Townshend, Alison Trainer, Lan Tran, Kathy Tucker, Janet Tyler, Jane Visvader, Logan Walker, Ian Walpole, Robin Ward, Paul Waring, Bev Warner, Graham Warren, Rachael Williams, Judy Wilson, Ingrid Winship, Kathy Wu, Mary Ann Young, D. Bowtell, A. Green, P. Webb, A. de Fazio, D. Gertig, kConFab/AOCS Investigators

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

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Abstract

Background: Annexin A1 (ANXA1) is a protein related with the carcinogenesis process and metastasis formation in many tumors. However, little is known about the prognostic value of ANXA1 in breast cancer. The purpose of this study is to evaluate the association between ANXA1 expression, BRCA1/2 germline carriership, specific tumor subtypes and survival in breast cancer patients. Methods: Clinical-pathological information and follow-up data were collected from nine breast cancer studies from the Breast Cancer Association Consortium (BCAC) (n = 5,752) and from one study of familial breast cancer patients with BRCA1/2 mutations (n = 107). ANXA1 expression was scored based on the percentage of immunohistochemical staining in tumor cells. Survival analyses were performed using a multivariable Cox model. Results: The frequency of ANXA1 positive tumors was higher in familial breast cancer patients with BRCA1/2 mutations than in BCAC patients, with 48.6% versus 12.4 %, respectively; P <0.0001. ANXA1 was also highly expressed in BCAC tumors that were poorly differentiated, triple negative, EGFR-CK5/6 positive or had developed in patients at a young age. In the first 5 years of follow-up, patients with ANXA1 positive tumors had a worse breast cancer-specific survival (BCSS) than ANXA1 negative (HR_adj = 1.35; 95 % CI = 1.05-1.73), but the association weakened after 10 years (HR_adj = 1.13; 95 % CI = 0.91-1.40). ANXA1 was a significant independent predictor of survival in HER2+ patients (10-years BCSS: HR_adj = 1.70; 95 % CI = 1.17-2.45). Conclusions: ANXA1 is overexpressed in familial breast cancer patients with BRCA1/2 mutations and correlated with poor prognosis features: triple negative and poorly differentiated tumors. ANXA1 might be a biomarker candidate for breast cancer survival prediction in high risk groups such as HER2+ cases.

Original language	English
Article number	156
Pages (from-to)	1-11
Number of pages	11
Journal	BMC Medicine
Volume	13
DOIs	https://doi.org/10.1186/s12916-015-0392-6
Publication status	Published - 2 Jul 2015
Externally published	Yes

Bibliographical note

Copyright the Author(s) 2015. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

Annexin A1
BRCA1 and BRCA2 mutations
Breast cancer

Access to Document

10.1186/s12916-015-0392-6

Publisher version (open access).pdfFinal published version, 1.84 MB

Cite this

Sobral-Leite, M., Wesseling, J., Smit, V. T. H. B. M., Nevanlinna, H., van Miltenburg, M. H., Sanders, J., Hofland, I., Blows, F. M., Coulson, P., Patrycja, G., Schellens, J. H. M., Fagerholm, R., Heikkilä, P., Aittomäki, K., Blomqvist, C., Provenzano, E., Ali, H. R., Figueroa, J., Sherman, M., ... kConFab/AOCS Investigators (2015). Annexin A1 expression in a pooled breast cancer series: Association with tumor subtypes and prognosis. BMC Medicine, 13, 1-11. [156]. https://doi.org/10.1186/s12916-015-0392-6

@article{8db3b0832ed24207b2f3c17ffa1a5089,

title = "Annexin A1 expression in a pooled breast cancer series: Association with tumor subtypes and prognosis",

abstract = "Background: Annexin A1 (ANXA1) is a protein related with the carcinogenesis process and metastasis formation in many tumors. However, little is known about the prognostic value of ANXA1 in breast cancer. The purpose of this study is to evaluate the association between ANXA1 expression, BRCA1/2 germline carriership, specific tumor subtypes and survival in breast cancer patients. Methods: Clinical-pathological information and follow-up data were collected from nine breast cancer studies from the Breast Cancer Association Consortium (BCAC) (n = 5,752) and from one study of familial breast cancer patients with BRCA1/2 mutations (n = 107). ANXA1 expression was scored based on the percentage of immunohistochemical staining in tumor cells. Survival analyses were performed using a multivariable Cox model. Results: The frequency of ANXA1 positive tumors was higher in familial breast cancer patients with BRCA1/2 mutations than in BCAC patients, with 48.6% versus 12.4 %, respectively; P <0.0001. ANXA1 was also highly expressed in BCAC tumors that were poorly differentiated, triple negative, EGFR-CK5/6 positive or had developed in patients at a young age. In the first 5 years of follow-up, patients with ANXA1 positive tumors had a worse breast cancer-specific survival (BCSS) than ANXA1 negative (HRadj = 1.35; 95 % CI = 1.05-1.73), but the association weakened after 10 years (HRadj = 1.13; 95 % CI = 0.91-1.40). ANXA1 was a significant independent predictor of survival in HER2+ patients (10-years BCSS: HRadj = 1.70; 95 % CI = 1.17-2.45). Conclusions: ANXA1 is overexpressed in familial breast cancer patients with BRCA1/2 mutations and correlated with poor prognosis features: triple negative and poorly differentiated tumors. ANXA1 might be a biomarker candidate for breast cancer survival prediction in high risk groups such as HER2+ cases.",

keywords = "Annexin A1, BRCA1 and BRCA2 mutations, Breast cancer",

author = "Marcelo Sobral-Leite and Jelle Wesseling and Smit, {Vincent T.H.B.M.} and Heli Nevanlinna and {van Miltenburg}, {Martine H.} and Joyce Sanders and Ingrid Hofland and Blows, {Fiona M.} and Penny Coulson and Gazinska Patrycja and Schellens, {Jan H.M.} and Rainer Fagerholm and P{\"a}ivi Heikkil{\"a} and Kristiina Aittom{\"a}ki and Carl Blomqvist and Elena Provenzano and Ali, {Hamid Raza} and Jonine Figueroa and Mark Sherman and Jolanta Lissowska and Arto Mannermaa and Vesa Kataja and Kosma, {Veli Matti} and Hartikainen, {Jaana M.} and Phillips, {Kelly Anne} and Couch, {Fergus J.} and Olson, {Janet E.} and Celine Vachon and Daniel Visscher and Hermann Brenner and Katja Butterbach and Volker Arndt and Bernd Holleczek and Hooning, {Maartje J.} and Antoinette Hollestelle and Martens, {John W.M.} and {van Deurzen}, {Carolien H.M.} and {van de Water}, Bob and Annegien Broeks and Jenny Chang-Claude and Georgia Chenevix-Trench and Easton, {Douglas F.} and Pharoah, {Paul D.P.} and Montserrat Garc{\'i}a-Closas and {de Graauw}, Marjo and Schmidt, {Marjanka K.} and Morteza Aghmesheh and David Amor and Lesley Andrews and Yoland Antill and Shane Armitage and Leanne Arnold and Rosemary Balleine and Agnes Bankier and Patti Bastick and Jonathan Beesley and John Beilby and Barbara Bennett and Ian Bennett and Geoffrey Berry and Anneke Blackburn and Michael Bogwitz and Meagan Brennan and Melissa Brown and Michael Buckley and Matthew Burgess and Jo Burke and Phyllis Butow and Keith Byron and David Callen and Ian Campbell and Deepa Chauhan and Manisha Chauhan and Alice Christian and Christine Clarke and Alison Colley and Dick Cotton and Ashley Crook and James Cui and Bronwyn Culling and Margaret Cummings and Dawson, {Sarah Jane} and Anna deFazio and Martin Delatycki and Rebecca Dickson and Joanne Dixon and Alexander Dobrovic and Tracy Dudding and Ted Edkins and Stacey Edwards and Maurice Eisenbruch and Gelareh Farshid and Susan Fawcett and Andrew Fellows and Georgina Fenton and Michael Field and Frank Firgaira and James Flanagan and Jean Fleming and Peter Fong and John Forbes and Stephen Fox and Juliet French and Michael Friedlander and Clara Gaff and Mac Gardner and Mike Gattas and Peter George and Graham Giles and Grantley Gill and Jack Goldblatt and Sian Greening and Scott Grist and Eric Haan and Kate Hardie and Marion Harris and Stewart Hart and Nick Hayward and Sue Healey and Louise Heiniger and John Hopper and Evelyn Humphrey and Clare Hunt and Paul James and Mark Jenkins and Alison Jones and Rick Kefford and Alexa Kidd and Belinda Kiely and Judy Kirk and Jessica Koehler and James Kollias and Serguei Kovalenko and Sunil Lakhani and Amanda Leaming and Jennifer Leary and Jacqueline Lim and Geoff Lindeman and Lara Lipton and Liz Lobb and Graham Mann and Deborah Marsh and McLachlan, {Sue Anne} and Bettina Meiser and Cliff Meldrum and Roger Milne and Gillian Mitchell and Beth Newman and Eveline Niedermayr and Sophie Nightingale and Shona O'Connell and Imelda O'Loughlin and Richard Osborne and Nick Pachter and Briony Patterson and Lester Peters and Kelly Phillips and Melanie Price and Lynne Purser and Tony Reeve and Jeanne Reeve and Robert Richards and Edwina Rickard and Bridget Robinson and Barney Rudzki and Mona Saleh and Elizabeth Salisbury and Joe Sambrook and Christobel Saunders and Jodi Saunus and Robyn Sayer and Elizabeth Scott and Rodney Scott and Clare Scott and Ram Seshadri and Adrienne Sexton and Raghwa Sharma and Andrew Shelling and Peter Simpson and Melissa Southey and Amanda Spurdle and Graeme Suthers and Pamela Sykes and Margaret Tassell and Donna Taylor and Jessica Taylor and Benjamin Thierry and Susan Thomas and Ella Thompson and Heather Thorne and Sharron Townshend and Alison Trainer and Lan Tran and Kathy Tucker and Janet Tyler and Jane Visvader and Logan Walker and Ian Walpole and Robin Ward and Paul Waring and Bev Warner and Graham Warren and Rachael Williams and Judy Wilson and Ingrid Winship and Kathy Wu and Young, {Mary Ann} and D. Bowtell and A. Green and P. Webb and {de Fazio}, A. and D. Gertig and {kConFab/AOCS Investigators}",

note = "Copyright the Author(s) 2015. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

year = "2015",

month = jul,

day = "2",

doi = "10.1186/s12916-015-0392-6",

language = "English",

volume = "13",

pages = "1--11",

journal = "BMC Medicine",

issn = "1741-7015",

publisher = "Springer, Springer Nature",

}

Sobral-Leite, M, Wesseling, J, Smit, VTHBM, Nevanlinna, H, van Miltenburg, MH, Sanders, J, Hofland, I, Blows, FM, Coulson, P, Patrycja, G, Schellens, JHM, Fagerholm, R, Heikkilä, P, Aittomäki, K, Blomqvist, C, Provenzano, E, Ali, HR, Figueroa, J, Sherman, M, Lissowska, J, Mannermaa, A, Kataja, V, Kosma, VM, Hartikainen, JM, Phillips, KA, Couch, FJ, Olson, JE, Vachon, C, Visscher, D, Brenner, H, Butterbach, K, Arndt, V, Holleczek, B, Hooning, MJ, Hollestelle, A, Martens, JWM, van Deurzen, CHM, van de Water, B, Broeks, A, Chang-Claude, J, Chenevix-Trench, G, Easton, DF, Pharoah, PDP, García-Closas, M, de Graauw, M, Schmidt, MK, Aghmesheh, M, Amor, D, Andrews, L, Antill, Y, Armitage, S, Arnold, L, Balleine, R, Bankier, A, Bastick, P, Beesley, J, Beilby, J, Bennett, B, Bennett, I, Berry, G, Blackburn, A, Bogwitz, M, Brennan, M, Brown, M, Buckley, M, Burgess, M, Burke, J, Butow, P, Byron, K, Callen, D, Campbell, I, Chauhan, D, Chauhan, M, Christian, A, Clarke, C, Colley, A, Cotton, D, Crook, A, Cui, J, Culling, B, Cummings, M, Dawson, SJ, deFazio, A, Delatycki, M, Dickson, R, Dixon, J, Dobrovic, A, Dudding, T, Edkins, T, Edwards, S, Eisenbruch, M, Farshid, G, Fawcett, S, Fellows, A, Fenton, G, Field, M, Firgaira, F, Flanagan, J, Fleming, J, Fong, P, Forbes, J, Fox, S, French, J, Friedlander, M, Gaff, C, Gardner, M, Gattas, M, George, P, Giles, G, Gill, G, Goldblatt, J, Greening, S, Grist, S, Haan, E, Hardie, K, Harris, M, Hart, S, Hayward, N, Healey, S, Heiniger, L, Hopper, J, Humphrey, E, Hunt, C, James, P, Jenkins, M, Jones, A, Kefford, R, Kidd, A, Kiely, B, Kirk, J, Koehler, J, Kollias, J, Kovalenko, S, Lakhani, S, Leaming, A, Leary, J, Lim, J, Lindeman, G, Lipton, L, Lobb, L, Mann, G, Marsh, D, McLachlan, SA, Meiser, B, Meldrum, C, Milne, R, Mitchell, G, Newman, B, Niedermayr, E, Nightingale, S, O'Connell, S, O'Loughlin, I, Osborne, R, Pachter, N, Patterson, B, Peters, L, Phillips, K, Price, M, Purser, L, Reeve, T, Reeve, J, Richards, R, Rickard, E, Robinson, B, Rudzki, B, Saleh, M, Salisbury, E, Sambrook, J, Saunders, C, Saunus, J, Sayer, R, Scott, E, Scott, R, Scott, C, Seshadri, R, Sexton, A, Sharma, R, Shelling, A, Simpson, P, Southey, M, Spurdle, A, Suthers, G, Sykes, P, Tassell, M, Taylor, D, Taylor, J, Thierry, B, Thomas, S, Thompson, E, Thorne, H, Townshend, S, Trainer, A, Tran, L, Tucker, K, Tyler, J, Visvader, J, Walker, L, Walpole, I, Ward, R, Waring, P, Warner, B, Warren, G, Williams, R, Wilson, J, Winship, I, Wu, K, Young, MA, Bowtell, D, Green, A, Webb, P, de Fazio, A, Gertig, D & kConFab/AOCS Investigators 2015, 'Annexin A1 expression in a pooled breast cancer series: Association with tumor subtypes and prognosis', BMC Medicine, vol. 13, 156, pp. 1-11. https://doi.org/10.1186/s12916-015-0392-6

TY - JOUR

T1 - Annexin A1 expression in a pooled breast cancer series

T2 - Association with tumor subtypes and prognosis

AU - Sobral-Leite, Marcelo

AU - Wesseling, Jelle

AU - Smit, Vincent T.H.B.M.

AU - Nevanlinna, Heli

AU - van Miltenburg, Martine H.

AU - Sanders, Joyce

AU - Hofland, Ingrid

AU - Blows, Fiona M.

AU - Coulson, Penny

AU - Patrycja, Gazinska

AU - Schellens, Jan H.M.

AU - Fagerholm, Rainer

AU - Heikkilä, Päivi

AU - Aittomäki, Kristiina

AU - Blomqvist, Carl

AU - Provenzano, Elena

AU - Ali, Hamid Raza

AU - Figueroa, Jonine

AU - Sherman, Mark

AU - Lissowska, Jolanta

AU - Mannermaa, Arto

AU - Kataja, Vesa

AU - Kosma, Veli Matti

AU - Hartikainen, Jaana M.

AU - Phillips, Kelly Anne

AU - Couch, Fergus J.

AU - Olson, Janet E.

AU - Vachon, Celine

AU - Visscher, Daniel

AU - Brenner, Hermann

AU - Butterbach, Katja

AU - Arndt, Volker

AU - Holleczek, Bernd

AU - Hooning, Maartje J.

AU - Hollestelle, Antoinette

AU - Martens, John W.M.

AU - van Deurzen, Carolien H.M.

AU - van de Water, Bob

AU - Broeks, Annegien

AU - Chang-Claude, Jenny

AU - Chenevix-Trench, Georgia

AU - Easton, Douglas F.

AU - Pharoah, Paul D.P.

AU - García-Closas, Montserrat

AU - de Graauw, Marjo

AU - Schmidt, Marjanka K.

AU - Aghmesheh, Morteza

AU - Amor, David

AU - Andrews, Lesley

AU - Antill, Yoland

AU - Armitage, Shane

AU - Arnold, Leanne

AU - Balleine, Rosemary

AU - Bankier, Agnes

AU - Bastick, Patti

AU - Beesley, Jonathan

AU - Beilby, John

AU - Bennett, Barbara

AU - Bennett, Ian

AU - Berry, Geoffrey

AU - Blackburn, Anneke

AU - Bogwitz, Michael

AU - Brennan, Meagan

AU - Brown, Melissa

AU - Buckley, Michael

AU - Burgess, Matthew

AU - Burke, Jo

AU - Butow, Phyllis

AU - Byron, Keith

AU - Callen, David

AU - Campbell, Ian

AU - Chauhan, Deepa

AU - Chauhan, Manisha

AU - Christian, Alice

AU - Clarke, Christine

AU - Colley, Alison

AU - Cotton, Dick

AU - Crook, Ashley

AU - Cui, James

AU - Culling, Bronwyn

AU - Cummings, Margaret

AU - Dawson, Sarah Jane

AU - deFazio, Anna

AU - Delatycki, Martin

AU - Dickson, Rebecca

AU - Dixon, Joanne

AU - Dobrovic, Alexander

AU - Dudding, Tracy

AU - Edkins, Ted

AU - Edwards, Stacey

AU - Eisenbruch, Maurice

AU - Farshid, Gelareh

AU - Fawcett, Susan

AU - Fellows, Andrew

AU - Fenton, Georgina

AU - Field, Michael

AU - Firgaira, Frank

AU - Flanagan, James

AU - Fleming, Jean

AU - Fong, Peter

AU - Forbes, John

AU - Fox, Stephen

AU - French, Juliet

AU - Friedlander, Michael

AU - Gaff, Clara

AU - Gardner, Mac

AU - Gattas, Mike

AU - George, Peter

AU - Giles, Graham

AU - Gill, Grantley

AU - Goldblatt, Jack

AU - Greening, Sian

AU - Grist, Scott

AU - Haan, Eric

AU - Hardie, Kate

AU - Harris, Marion

AU - Hart, Stewart

AU - Hayward, Nick

AU - Healey, Sue

AU - Heiniger, Louise

AU - Hopper, John

AU - Humphrey, Evelyn

AU - Hunt, Clare

AU - James, Paul

AU - Jenkins, Mark

AU - Jones, Alison

AU - Kefford, Rick

AU - Kidd, Alexa

AU - Kiely, Belinda

AU - Kirk, Judy

AU - Koehler, Jessica

AU - Kollias, James

AU - Kovalenko, Serguei

AU - Lakhani, Sunil

AU - Leaming, Amanda

AU - Leary, Jennifer

AU - Lim, Jacqueline

AU - Lindeman, Geoff

AU - Lipton, Lara

AU - Lobb, Liz

AU - Mann, Graham

AU - Marsh, Deborah

AU - McLachlan, Sue Anne

AU - Meiser, Bettina

AU - Meldrum, Cliff

AU - Milne, Roger

AU - Mitchell, Gillian

AU - Newman, Beth

AU - Niedermayr, Eveline

AU - Nightingale, Sophie

AU - O'Connell, Shona

AU - O'Loughlin, Imelda

AU - Osborne, Richard

AU - Pachter, Nick

AU - Patterson, Briony

AU - Peters, Lester

AU - Phillips, Kelly

AU - Price, Melanie

AU - Purser, Lynne

AU - Reeve, Tony

AU - Reeve, Jeanne

AU - Richards, Robert

AU - Rickard, Edwina

AU - Robinson, Bridget

AU - Rudzki, Barney

AU - Saleh, Mona

AU - Salisbury, Elizabeth

AU - Sambrook, Joe

AU - Saunders, Christobel

AU - Saunus, Jodi

AU - Sayer, Robyn

AU - Scott, Elizabeth

AU - Scott, Rodney

AU - Scott, Clare

AU - Seshadri, Ram

AU - Sexton, Adrienne

AU - Sharma, Raghwa

AU - Shelling, Andrew

AU - Simpson, Peter

AU - Southey, Melissa

AU - Spurdle, Amanda

AU - Suthers, Graeme

AU - Sykes, Pamela

AU - Tassell, Margaret

AU - Taylor, Donna

AU - Taylor, Jessica

AU - Thierry, Benjamin

AU - Thomas, Susan

AU - Thompson, Ella

AU - Thorne, Heather

AU - Townshend, Sharron

AU - Trainer, Alison

AU - Tran, Lan

AU - Tucker, Kathy

AU - Tyler, Janet

AU - Visvader, Jane

AU - Walker, Logan

AU - Walpole, Ian

AU - Ward, Robin

AU - Waring, Paul

AU - Warner, Bev

AU - Warren, Graham

AU - Williams, Rachael

AU - Wilson, Judy

AU - Winship, Ingrid

AU - Wu, Kathy

AU - Young, Mary Ann

AU - Bowtell, D.

AU - Green, A.

AU - Webb, P.

AU - de Fazio, A.

AU - Gertig, D.

AU - kConFab/AOCS Investigators

N1 - Copyright the Author(s) 2015. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2015/7/2

Y1 - 2015/7/2

N2 - Background: Annexin A1 (ANXA1) is a protein related with the carcinogenesis process and metastasis formation in many tumors. However, little is known about the prognostic value of ANXA1 in breast cancer. The purpose of this study is to evaluate the association between ANXA1 expression, BRCA1/2 germline carriership, specific tumor subtypes and survival in breast cancer patients. Methods: Clinical-pathological information and follow-up data were collected from nine breast cancer studies from the Breast Cancer Association Consortium (BCAC) (n = 5,752) and from one study of familial breast cancer patients with BRCA1/2 mutations (n = 107). ANXA1 expression was scored based on the percentage of immunohistochemical staining in tumor cells. Survival analyses were performed using a multivariable Cox model. Results: The frequency of ANXA1 positive tumors was higher in familial breast cancer patients with BRCA1/2 mutations than in BCAC patients, with 48.6% versus 12.4 %, respectively; P <0.0001. ANXA1 was also highly expressed in BCAC tumors that were poorly differentiated, triple negative, EGFR-CK5/6 positive or had developed in patients at a young age. In the first 5 years of follow-up, patients with ANXA1 positive tumors had a worse breast cancer-specific survival (BCSS) than ANXA1 negative (HRadj = 1.35; 95 % CI = 1.05-1.73), but the association weakened after 10 years (HRadj = 1.13; 95 % CI = 0.91-1.40). ANXA1 was a significant independent predictor of survival in HER2+ patients (10-years BCSS: HRadj = 1.70; 95 % CI = 1.17-2.45). Conclusions: ANXA1 is overexpressed in familial breast cancer patients with BRCA1/2 mutations and correlated with poor prognosis features: triple negative and poorly differentiated tumors. ANXA1 might be a biomarker candidate for breast cancer survival prediction in high risk groups such as HER2+ cases.

AB - Background: Annexin A1 (ANXA1) is a protein related with the carcinogenesis process and metastasis formation in many tumors. However, little is known about the prognostic value of ANXA1 in breast cancer. The purpose of this study is to evaluate the association between ANXA1 expression, BRCA1/2 germline carriership, specific tumor subtypes and survival in breast cancer patients. Methods: Clinical-pathological information and follow-up data were collected from nine breast cancer studies from the Breast Cancer Association Consortium (BCAC) (n = 5,752) and from one study of familial breast cancer patients with BRCA1/2 mutations (n = 107). ANXA1 expression was scored based on the percentage of immunohistochemical staining in tumor cells. Survival analyses were performed using a multivariable Cox model. Results: The frequency of ANXA1 positive tumors was higher in familial breast cancer patients with BRCA1/2 mutations than in BCAC patients, with 48.6% versus 12.4 %, respectively; P <0.0001. ANXA1 was also highly expressed in BCAC tumors that were poorly differentiated, triple negative, EGFR-CK5/6 positive or had developed in patients at a young age. In the first 5 years of follow-up, patients with ANXA1 positive tumors had a worse breast cancer-specific survival (BCSS) than ANXA1 negative (HRadj = 1.35; 95 % CI = 1.05-1.73), but the association weakened after 10 years (HRadj = 1.13; 95 % CI = 0.91-1.40). ANXA1 was a significant independent predictor of survival in HER2+ patients (10-years BCSS: HRadj = 1.70; 95 % CI = 1.17-2.45). Conclusions: ANXA1 is overexpressed in familial breast cancer patients with BRCA1/2 mutations and correlated with poor prognosis features: triple negative and poorly differentiated tumors. ANXA1 might be a biomarker candidate for breast cancer survival prediction in high risk groups such as HER2+ cases.

KW - Annexin A1

KW - BRCA1 and BRCA2 mutations

KW - Breast cancer

UR - http://www.scopus.com/inward/record.url?scp=84935085249&partnerID=8YFLogxK

U2 - 10.1186/s12916-015-0392-6

DO - 10.1186/s12916-015-0392-6

M3 - Article

C2 - 26137966

AN - SCOPUS:84935085249

SN - 1741-7015

VL - 13

SP - 1

EP - 11

JO - BMC Medicine

JF - BMC Medicine

M1 - 156

ER -

Annexin A1 expression in a pooled breast cancer series: Association with tumor subtypes and prognosis

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