Anthracene-modified oligonucleotides as fluorescent DNA mismatch sensors: discrimination between various base-pair mismatches

Jean Louis H A Duprey; Dario M. Bassani; Eva I. Hyde; Christian Ludwig; Alison Rodger; Joseph S. Vyle; John Wilkie; Zheng Yun Zhao; James H R Tucker

doi:10.1080/10610278.2010.523117

Anthracene-modified oligonucleotides as fluorescent DNA mismatch sensors: discrimination between various base-pair mismatches

Jean Louis H A Duprey, Dario M. Bassani, Eva I. Hyde, Christian Ludwig, Alison Rodger, Joseph S. Vyle, John Wilkie, Zheng Yun Zhao, James H R Tucker

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

A fluorescent anthracene-tagged DNA probe has been shown to respond to various DNA sequences by changes to its emission signal upon duplex formation. The fluorescence response for duplexes containing a single mismatch near the anthracene site has been found to be very sensitive to its composition, with the emission signal increasing for a CA mismatch and decreasing for CT and CC mismatches.

Original language	English
Pages (from-to)	273-277
Number of pages	5
Journal	Supramolecular Chemistry
Volume	23
Issue number	3-4
DOIs	https://doi.org/10.1080/10610278.2010.523117
Publication status	Published - Mar 2011
Externally published	Yes

Keywords

Anthracene
DNA
Fluorescence
Sensor
SNP

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10.1080/10610278.2010.523117

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abstract = "A fluorescent anthracene-tagged DNA probe has been shown to respond to various DNA sequences by changes to its emission signal upon duplex formation. The fluorescence response for duplexes containing a single mismatch near the anthracene site has been found to be very sensitive to its composition, with the emission signal increasing for a CA mismatch and decreasing for CT and CC mismatches.",

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AU - Duprey, Jean Louis H A

AU - Bassani, Dario M.

AU - Hyde, Eva I.

AU - Ludwig, Christian

AU - Rodger, Alison

AU - Vyle, Joseph S.

AU - Wilkie, John

AU - Zhao, Zheng Yun

AU - Tucker, James H R

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AB - A fluorescent anthracene-tagged DNA probe has been shown to respond to various DNA sequences by changes to its emission signal upon duplex formation. The fluorescence response for duplexes containing a single mismatch near the anthracene site has been found to be very sensitive to its composition, with the emission signal increasing for a CA mismatch and decreasing for CT and CC mismatches.

KW - Anthracene

KW - DNA

KW - Fluorescence

KW - Sensor

KW - SNP

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DO - 10.1080/10610278.2010.523117

M3 - Article

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IS - 3-4

ER -

Anthracene-modified oligonucleotides as fluorescent DNA mismatch sensors: discrimination between various base-pair mismatches

Abstract

Keywords

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