Anthracene-modified oligonucleotides as fluorescent DNA mismatch sensors

discrimination between various base-pair mismatches

Jean Louis H A Duprey, Dario M. Bassani, Eva I. Hyde, Christian Ludwig, Alison Rodger, Joseph S. Vyle, John Wilkie, Zheng Yun Zhao, James H R Tucker

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A fluorescent anthracene-tagged DNA probe has been shown to respond to various DNA sequences by changes to its emission signal upon duplex formation. The fluorescence response for duplexes containing a single mismatch near the anthracene site has been found to be very sensitive to its composition, with the emission signal increasing for a CA mismatch and decreasing for CT and CC mismatches.

Original languageEnglish
Pages (from-to)273-277
Number of pages5
JournalSupramolecular Chemistry
Volume23
Issue number3-4
DOIs
Publication statusPublished - Mar 2011
Externally publishedYes

Keywords

  • Anthracene
  • DNA
  • Fluorescence
  • Sensor
  • SNP

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