Anthranilamide-based short peptides self-assembled hydrogels as antibacterial agents

Vina R. Aldilla, Renxun Chen, Adam D. Martin, Christopher E. Marjo, Anne M. Rich, David St C. Black, Pall Thordarson, Naresh Kumar*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

In this study, we describe the synthesis and molecular properties of anthranilamide-based short peptides which were synthesised via ring opening of isatoic anhydride in excellent yields. These short peptides were incorporated as low molecular weight gelators (LMWG), bola amphiphile, and C3-symmetric molecules to form hydrogels in low concentrations (0.07–0.30% (w/v)). The critical gel concentration (CGC), viscoelastic properties, secondary structure, and fibre morphology of these short peptides were influenced by the aromaticity of the capping group or by the presence of electronegative substituent (namely fluoro) and hydrophobic substituent (such as methyl) in the short peptides. In addition, the hydrogels showed antibacterial activity against S. aureus 38 and moderate toxicity against HEK cells in vitro.

Original languageEnglish
Article number770
Pages (from-to)1-12
Number of pages12
JournalScientific Reports
Volume10
Issue number1
DOIs
Publication statusPublished - 21 Jan 2020

Bibliographical note

Copyright the Author(s) 2020. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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