Anti-diabetic effect of isoflavone rich kudzu root extract in experimentally induced diabetic rats

Kingsley C. Duru, Elena A. Mukhlynina, Gleb A. Moroz, Irina F. Gette, Irina G. Danilova, Elena G. Kovaleva

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2 Citations (Scopus)
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Abstract

The anti-diabetic effect of isoflavone-rich kudzu extract obtained using natural deep eutectic solvent was assessed in diabetic wistar rats treated at doses of 100 mg/kg or 200 mg/kg for 28 days. Effect of treatment was based on weight, glucose tolerance, fasting glucose and glycated haemoglobin level, hepatic biochemical parameters, expression of anti-insulin and Ki67 antibodies, and histopathological evaluation of pancreas and kidney tissues. We found overall improvement in weight in diabetic rats treated with the extract at dose 200 mg/kg, but not at dose of 100 mg/kg. Plasma level of alanine transaminase (ALT) and aspartate aminotransferase (AST), but not alkaline phosphatase (ALP), were significantly different between untreated diabetic rats and those treated with the extract (p = 0.05). We found that the isoflavones-rich extract stimulated β-cell regeneration in a dose-dependent effect and showed no observable toxic impact in either the kidney or pancreas. Thus, this extract may be a promising treatment option for diabetic condition.
Original languageEnglish
Article number103922
Pages (from-to)1-11
Number of pages11
JournalJournal of Functional Foods
Volume68
DOIs
Publication statusPublished - May 2020

Bibliographical note

Copyright the Author(s) 2020. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • Isoflavones
  • Pueraria lobata
  • Diabetes
  • Pancreatic islet
  • Glycosylated haemoglobin

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