Anti-inflammatory activities of Coleus forsteri (formerly Plectranthus forsteri) extracts on human macrophages and chemical characterization

Mael Nicolas; Malia Lasalo; Sharron Chow; Cyril Antheaume; Karl Huet; Edouard Hnawia; Gilles J. Guillemin; Mohammed Nour; Mariko Matsui

doi:10.3389/fphar.2022.1081310

Anti-inflammatory activities of Coleus forsteri (formerly Plectranthus forsteri) extracts on human macrophages and chemical characterization

Mael Nicolas, Malia Lasalo, Sharron Chow, Cyril Antheaume, Karl Huet, Edouard Hnawia, Gilles J. Guillemin, Mohammed Nour, Mariko Matsui

Macquarie Medical School

Research output: Contribution to journal › Article › peer-review

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Abstract

Introduction: Formerly named Plectranthus forsteri, Coleus forsteri (Benth.) A.J.Paton, 2019 is a Lamiaceae traditionally used to treat flu-like symptoms and shock-related ecchymosis, especially in the Pacific region. Few studies investigated chemical composition and anti-inflammatory potential of this plant. Method: Herein, we investigated anti-inflammatory potential of C. forsteri ethanolic (ePE) and cyclohexane (cPE) plant extract on LPS-induced human macrophages models and quantified cytokines and quinolinic acid (QUIN) as inflammatory markers. Results: Our results show that extract of ePE and cPE significantly inhibit inflammatory cytokine IL-6 and TNF-α induced by LPS on PMA-derived THP-1 macrophages. QUIN production is also diminished under ePE and cPE treatment in activated human monocyte-derived macrophages (MDMs). Seven abietane diterpenes were characterized from C. forsteri cPE including coleon U ( 1), coleon U-quinone ( 2), 8α,9α-epoxycoleon U-quinone ( 3), horminone or 7α-hydroxyroyleanone ( 4), 6β,7α-dihydroxyroyleanone ( 5), 7α-acetoxy-6β-hydroxyroyleanone ( 6) and 7α-formyloxy-6β-hydroxyroyleanone ( 7). Discussion: We discussed potential contributions of these molecules from C. forsteri extracts for their anti-inflammatory activities.

Original language	English
Article number	1081310
Pages (from-to)	1-12
Number of pages	12
Journal	Frontiers in Pharmacology
Volume	13
DOIs	https://doi.org/10.3389/fphar.2022.1081310
Publication status	Published - 9 Jan 2023

Bibliographical note

Copyright the Author(s) 2023. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

Coleus forsteri
traditional plant
anti-inflammatory
macrophage
cytokine
quinolinic acid (QUIN)
abietane
diterpene

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10.3389/fphar.2022.1081310Licence: CC BY

Publisher version (open access)Final published version, 1.76 MBLicence: CC BY

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title = "Anti-inflammatory activities of Coleus forsteri (formerly Plectranthus forsteri) extracts on human macrophages and chemical characterization",

abstract = " Introduction: Formerly named Plectranthus forsteri, Coleus forsteri (Benth.) A.J.Paton, 2019 is a Lamiaceae traditionally used to treat flu-like symptoms and shock-related ecchymosis, especially in the Pacific region. Few studies investigated chemical composition and anti-inflammatory potential of this plant. Method: Herein, we investigated anti-inflammatory potential of C. forsteri ethanolic (ePE) and cyclohexane (cPE) plant extract on LPS-induced human macrophages models and quantified cytokines and quinolinic acid (QUIN) as inflammatory markers. Results: Our results show that extract of ePE and cPE significantly inhibit inflammatory cytokine IL-6 and TNF-α induced by LPS on PMA-derived THP-1 macrophages. QUIN production is also diminished under ePE and cPE treatment in activated human monocyte-derived macrophages (MDMs). Seven abietane diterpenes were characterized from C. forsteri cPE including coleon U ( 1), coleon U-quinone ( 2), 8α,9α-epoxycoleon U-quinone ( 3), horminone or 7α-hydroxyroyleanone ( 4), 6β,7α-dihydroxyroyleanone ( 5), 7α-acetoxy-6β-hydroxyroyleanone ( 6) and 7α-formyloxy-6β-hydroxyroyleanone ( 7). Discussion: We discussed potential contributions of these molecules from C. forsteri extracts for their anti-inflammatory activities. ",

keywords = "Coleus forsteri, traditional plant, anti-inflammatory, macrophage, cytokine, quinolinic acid (QUIN), abietane, diterpene",

author = "Mael Nicolas and Malia Lasalo and Sharron Chow and Cyril Antheaume and Karl Huet and Edouard Hnawia and Guillemin, {Gilles J.} and Mohammed Nour and Mariko Matsui",

note = "Copyright the Author(s) 2023. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

year = "2023",

month = jan,

day = "9",

doi = "10.3389/fphar.2022.1081310",

language = "English",

volume = "13",

pages = "1--12",

journal = "Frontiers in Pharmacology",

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TY - JOUR

T1 - Anti-inflammatory activities of Coleus forsteri (formerly Plectranthus forsteri) extracts on human macrophages and chemical characterization

AU - Nicolas, Mael

AU - Lasalo, Malia

AU - Chow, Sharron

AU - Antheaume, Cyril

AU - Huet, Karl

AU - Hnawia, Edouard

AU - Guillemin, Gilles J.

AU - Nour, Mohammed

AU - Matsui, Mariko

N1 - Copyright the Author(s) 2023. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2023/1/9

Y1 - 2023/1/9

N2 - Introduction: Formerly named Plectranthus forsteri, Coleus forsteri (Benth.) A.J.Paton, 2019 is a Lamiaceae traditionally used to treat flu-like symptoms and shock-related ecchymosis, especially in the Pacific region. Few studies investigated chemical composition and anti-inflammatory potential of this plant. Method: Herein, we investigated anti-inflammatory potential of C. forsteri ethanolic (ePE) and cyclohexane (cPE) plant extract on LPS-induced human macrophages models and quantified cytokines and quinolinic acid (QUIN) as inflammatory markers. Results: Our results show that extract of ePE and cPE significantly inhibit inflammatory cytokine IL-6 and TNF-α induced by LPS on PMA-derived THP-1 macrophages. QUIN production is also diminished under ePE and cPE treatment in activated human monocyte-derived macrophages (MDMs). Seven abietane diterpenes were characterized from C. forsteri cPE including coleon U ( 1), coleon U-quinone ( 2), 8α,9α-epoxycoleon U-quinone ( 3), horminone or 7α-hydroxyroyleanone ( 4), 6β,7α-dihydroxyroyleanone ( 5), 7α-acetoxy-6β-hydroxyroyleanone ( 6) and 7α-formyloxy-6β-hydroxyroyleanone ( 7). Discussion: We discussed potential contributions of these molecules from C. forsteri extracts for their anti-inflammatory activities.

AB - Introduction: Formerly named Plectranthus forsteri, Coleus forsteri (Benth.) A.J.Paton, 2019 is a Lamiaceae traditionally used to treat flu-like symptoms and shock-related ecchymosis, especially in the Pacific region. Few studies investigated chemical composition and anti-inflammatory potential of this plant. Method: Herein, we investigated anti-inflammatory potential of C. forsteri ethanolic (ePE) and cyclohexane (cPE) plant extract on LPS-induced human macrophages models and quantified cytokines and quinolinic acid (QUIN) as inflammatory markers. Results: Our results show that extract of ePE and cPE significantly inhibit inflammatory cytokine IL-6 and TNF-α induced by LPS on PMA-derived THP-1 macrophages. QUIN production is also diminished under ePE and cPE treatment in activated human monocyte-derived macrophages (MDMs). Seven abietane diterpenes were characterized from C. forsteri cPE including coleon U ( 1), coleon U-quinone ( 2), 8α,9α-epoxycoleon U-quinone ( 3), horminone or 7α-hydroxyroyleanone ( 4), 6β,7α-dihydroxyroyleanone ( 5), 7α-acetoxy-6β-hydroxyroyleanone ( 6) and 7α-formyloxy-6β-hydroxyroyleanone ( 7). Discussion: We discussed potential contributions of these molecules from C. forsteri extracts for their anti-inflammatory activities.

KW - Coleus forsteri

KW - traditional plant

KW - anti-inflammatory

KW - macrophage

KW - cytokine

KW - quinolinic acid (QUIN)

KW - abietane

KW - diterpene

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U2 - 10.3389/fphar.2022.1081310

DO - 10.3389/fphar.2022.1081310

M3 - Article

C2 - 36699063

SN - 1663-9812

VL - 13

SP - 1

EP - 12

JO - Frontiers in Pharmacology

JF - Frontiers in Pharmacology

M1 - 1081310

ER -

Anti-inflammatory activities of Coleus forsteri (formerly Plectranthus forsteri) extracts on human macrophages and chemical characterization

Abstract

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Keywords

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