Anti-inflammatory and neuropharmacological activities of Caesalpinia pulcherrima bark

Utpal Bose*, Lubna Hossain, Vaskor Bala, Ananda Kumar Shill, Ahmed Ayedur Rahman

*Corresponding author for this work

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The crude methanolic extracts of bark of Caesalpinia pulcherrima were evaluated for its anti-inflammatory and neuropharmacological activities. When given orally to rats at dose of 200 and 400 mg/kg, the extract showed a significant (P<0.001) anti-inflammatory activity against carrageenin induced paw edema in rats comparable to the standard drug phenyl butazone. The extract of Caesalpinia pulcherrima barks also potentiated the pentobarbital induced sleeping time in mice, and decreased the open field score in open field test, decreased the number of hole crossed from one chamber in the hole cross test and decreased the head dip responses in hole board test.

Original languageEnglish
Pages (from-to)77-84
Number of pages8
JournalResearch Journal of Pharmaceutical, Biological and Chemical Sciences
Volume2
Issue number1
Publication statusPublished - Jan 2011
Externally publishedYes

Keywords

  • anti-inflammatory
  • antidiarrhoeal
  • neuropharmacological
  • Caesalpinia pulcherrima

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