Antibacterial compounds from Carissa lanceolata R.Br

Elizabeth A. Lindsay; Yoke Berry; Joanne F. Jamie; John B. Bremner

doi:10.1016/S0031-9422(00)00343-5

Antibacterial compounds from Carissa lanceolata R.Br

Elizabeth A. Lindsay, Yoke Berry, Joanne F. Jamie^*, John B. Bremner

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

The dichloromethane extract of the wood of Carissa lanceolata R.Br. (Apocynaceae) afforded the eudesmanes carissone, dehydrocarissone and carindone. This is the first account of carissone being isolated from the wood of C. lanceolata, and of carindone being isolated from this Carissa species. Dehydrocarissone has not been isolated previously from any Carissa species. The anti-bacterial activity of these natural products were examined against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. All three compounds showed activity, with dehydrocarissone and carindone having a minimum inhibitory concentration less than 0.5 mg/ml against S. aureus and E. coli. (C) 2000 Elsevier Science Ltd.

Original language	English
Pages (from-to)	403-406
Number of pages	4
Journal	Phytochemistry
Volume	55
Issue number	5
DOIs	https://doi.org/10.1016/S0031-9422(00)00343-5
Publication status	Published - 28 Nov 2000

Keywords

Apocynaceae
Carindone
Carissa lanceolata
Carissone
Conkerberry
Dehydrocarissone

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10.1016/S0031-9422(00)00343-5

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title = "Antibacterial compounds from Carissa lanceolata R.Br",

abstract = "The dichloromethane extract of the wood of Carissa lanceolata R.Br. (Apocynaceae) afforded the eudesmanes carissone, dehydrocarissone and carindone. This is the first account of carissone being isolated from the wood of C. lanceolata, and of carindone being isolated from this Carissa species. Dehydrocarissone has not been isolated previously from any Carissa species. The anti-bacterial activity of these natural products were examined against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. All three compounds showed activity, with dehydrocarissone and carindone having a minimum inhibitory concentration less than 0.5 mg/ml against S. aureus and E. coli. (C) 2000 Elsevier Science Ltd.",

keywords = "Apocynaceae, Carindone, Carissa lanceolata, Carissone, Conkerberry, Dehydrocarissone",

author = "Lindsay, {Elizabeth A.} and Yoke Berry and Jamie, {Joanne F.} and Bremner, {John B.}",

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TY - JOUR

T1 - Antibacterial compounds from Carissa lanceolata R.Br

AU - Lindsay, Elizabeth A.

AU - Berry, Yoke

AU - Jamie, Joanne F.

AU - Bremner, John B.

PY - 2000/11/28

Y1 - 2000/11/28

N2 - The dichloromethane extract of the wood of Carissa lanceolata R.Br. (Apocynaceae) afforded the eudesmanes carissone, dehydrocarissone and carindone. This is the first account of carissone being isolated from the wood of C. lanceolata, and of carindone being isolated from this Carissa species. Dehydrocarissone has not been isolated previously from any Carissa species. The anti-bacterial activity of these natural products were examined against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. All three compounds showed activity, with dehydrocarissone and carindone having a minimum inhibitory concentration less than 0.5 mg/ml against S. aureus and E. coli. (C) 2000 Elsevier Science Ltd.

AB - The dichloromethane extract of the wood of Carissa lanceolata R.Br. (Apocynaceae) afforded the eudesmanes carissone, dehydrocarissone and carindone. This is the first account of carissone being isolated from the wood of C. lanceolata, and of carindone being isolated from this Carissa species. Dehydrocarissone has not been isolated previously from any Carissa species. The anti-bacterial activity of these natural products were examined against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. All three compounds showed activity, with dehydrocarissone and carindone having a minimum inhibitory concentration less than 0.5 mg/ml against S. aureus and E. coli. (C) 2000 Elsevier Science Ltd.

KW - Apocynaceae

KW - Carindone

KW - Carissa lanceolata

KW - Carissone

KW - Conkerberry

KW - Dehydrocarissone

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U2 - 10.1016/S0031-9422(00)00343-5

DO - 10.1016/S0031-9422(00)00343-5

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AN - SCOPUS:0034727720

SN - 0031-9422

VL - 55

SP - 403

EP - 406

JO - Phytochemistry

JF - Phytochemistry

IS - 5

ER -

Antibacterial compounds from Carissa lanceolata R.Br

Abstract

Keywords

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