Antibacterial compounds from Carissa lanceolata R.Br

Elizabeth A. Lindsay, Yoke Berry, Joanne F. Jamie*, John B. Bremner

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

The dichloromethane extract of the wood of Carissa lanceolata R.Br. (Apocynaceae) afforded the eudesmanes carissone, dehydrocarissone and carindone. This is the first account of carissone being isolated from the wood of C. lanceolata, and of carindone being isolated from this Carissa species. Dehydrocarissone has not been isolated previously from any Carissa species. The anti-bacterial activity of these natural products were examined against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. All three compounds showed activity, with dehydrocarissone and carindone having a minimum inhibitory concentration less than 0.5 mg/ml against S. aureus and E. coli. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)403-406
Number of pages4
JournalPhytochemistry
Volume55
Issue number5
DOIs
Publication statusPublished - 28 Nov 2000

Keywords

  • Apocynaceae
  • Carindone
  • Carissa lanceolata
  • Carissone
  • Conkerberry
  • Dehydrocarissone

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