Antibodies to MOG are transient in childhood acute disseminated encephalomyelitis

A. K. Pröbstel, K. Dornmair, R. Bittner, P. Sperl, D. Jenne, S. Magalhaes, A. Villalobos, C. Breithaupt, R. Weissert, U. Jacob, M. Krumbholz, T. Kuempfel, A. Blaschek, W. Stark, J. Gärtner, D. Pohl, K. Rostasy, F. Weber, I. Forne, M. KhademiT. Olsson, F. Brilot, E. Tantsis, R. C. Dale, H. Wekerle, R. Hohlfeld, B. Banwell, A. Bar-Or, E. Meinl*, T. Derfuss

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

233 Citations (Scopus)


Objective: To study the longitudinal dynamics of anti-myelin oligodendrocyte glycoprotein (MOG) autoantibodies in childhood demyelinating diseases. Methods: We addressed the kinetics of anti-MOG immunoglobulins in a prospective study comprising 77 pediatric patients. This was supplemented by a cross-sectional study analyzing 126 pediatric patients with acute demyelination and 62 adult patients with multiple sclerosis (MS). MOG-transfected cells were used for detection of antibodies by flow cytometry. Results: Twenty-five children who were anti-MOG immunoglobulin (Ig) positive at disease onset were followed for up to 5 years. Anti-MOG antibodies rapidly and continuously declined in all 16 monophasic patients with acute disseminated encephalomyelitis and in one patient with clinically isolated syndrome. In contrast, in 6 of 8 patients (75%) eventually diagnosed with childhood MS, the antibodies to MOG persisted with fluctuations showing a second increase during an observation period of up to 5 years. Antibodies to MOG were mainly IgG 1 and their binding was largely blocked by pathogenic anti-MOG antibodies derived from a spontaneous animal model of autoimmune encephalitis. The cross-sectional part of our study elaborated that anti-MOG Ig was present in about 25% of children with acute demyelination, but in none of the pediatric or adult controls. Sera from 4/62 (6%) adult patients with MS had anti-MOG IgG at low levels. Conclusions: The persistence or disappearance of antibodies to MOG may have prognostic relevance for acute childhood demyelination.

Original languageEnglish
Pages (from-to)580-588
Number of pages9
Issue number6
Publication statusPublished - 9 Aug 2011
Externally publishedYes


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