Anticipation of onset age in familial Parkinson's disease without SCA gene mutations

Yue Huang; Michael Hayes; Antony J. Harding; William S. Brooks; Victor S.C. Fung; Dominic Rowe; Ron Joffe; Denis Crimmins; Mariese Hely; Glenda M. Halliday

doi:10.1016/j.parkreldis.2006.01.002

Anticipation of onset age in familial Parkinson's disease without SCA gene mutations

Yue Huang, Michael Hayes, Antony J. Harding, William S. Brooks, Victor S.C. Fung, Dominic Rowe, Ron Joffe, Denis Crimmins, Mariese Hely, Glenda M. Halliday^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Assessment of a series of 279 cases with Lewy body disease revealed 14 families having a family history consistent with autosomal dominant inheritance, eight of these with dominant Parkinsonism and six with dominant dementia. Analysis of the age at onset and genetic features in these families revealed significant anticipation only in a subset of parkinsonian families, with no pathological alleles for spinocerebellar ataxias or the common α-synuclein or LRRK2 point mutations.

Original language	English
Pages (from-to)	309-313
Number of pages	5
Journal	Parkinsonism and Related Disorders
Volume	12
Issue number	5
DOIs	https://doi.org/10.1016/j.parkreldis.2006.01.002
Publication status	Published - Jun 2006
Externally published	Yes

Keywords

Anticipation
Autosomal dominant inheritance
Dementia with Lewy bodies
Parkinson's disease

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10.1016/j.parkreldis.2006.01.002

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title = "Anticipation of onset age in familial Parkinson's disease without SCA gene mutations",

abstract = "Assessment of a series of 279 cases with Lewy body disease revealed 14 families having a family history consistent with autosomal dominant inheritance, eight of these with dominant Parkinsonism and six with dominant dementia. Analysis of the age at onset and genetic features in these families revealed significant anticipation only in a subset of parkinsonian families, with no pathological alleles for spinocerebellar ataxias or the common α-synuclein or LRRK2 point mutations.",

keywords = "Anticipation, Autosomal dominant inheritance, Dementia with Lewy bodies, Parkinson's disease",

author = "Yue Huang and Michael Hayes and Harding, {Antony J.} and Brooks, {William S.} and Fung, {Victor S.C.} and Dominic Rowe and Ron Joffe and Denis Crimmins and Mariese Hely and Halliday, {Glenda M.}",

year = "2006",

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language = "English",

volume = "12",

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journal = "Parkinsonism and Related Disorders",

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TY - JOUR

T1 - Anticipation of onset age in familial Parkinson's disease without SCA gene mutations

AU - Huang, Yue

AU - Hayes, Michael

AU - Harding, Antony J.

AU - Brooks, William S.

AU - Fung, Victor S.C.

AU - Rowe, Dominic

AU - Joffe, Ron

AU - Crimmins, Denis

AU - Hely, Mariese

AU - Halliday, Glenda M.

PY - 2006/6

Y1 - 2006/6

N2 - Assessment of a series of 279 cases with Lewy body disease revealed 14 families having a family history consistent with autosomal dominant inheritance, eight of these with dominant Parkinsonism and six with dominant dementia. Analysis of the age at onset and genetic features in these families revealed significant anticipation only in a subset of parkinsonian families, with no pathological alleles for spinocerebellar ataxias or the common α-synuclein or LRRK2 point mutations.

AB - Assessment of a series of 279 cases with Lewy body disease revealed 14 families having a family history consistent with autosomal dominant inheritance, eight of these with dominant Parkinsonism and six with dominant dementia. Analysis of the age at onset and genetic features in these families revealed significant anticipation only in a subset of parkinsonian families, with no pathological alleles for spinocerebellar ataxias or the common α-synuclein or LRRK2 point mutations.

KW - Anticipation

KW - Autosomal dominant inheritance

KW - Dementia with Lewy bodies

KW - Parkinson's disease

UR - http://www.scopus.com/inward/record.url?scp=33744513034&partnerID=8YFLogxK

U2 - 10.1016/j.parkreldis.2006.01.002

DO - 10.1016/j.parkreldis.2006.01.002

M3 - Article

C2 - 16621662

AN - SCOPUS:33744513034

SN - 1353-8020

VL - 12

SP - 309

EP - 313

JO - Parkinsonism and Related Disorders

JF - Parkinsonism and Related Disorders

IS - 5

ER -

Anticipation of onset age in familial Parkinson's disease without SCA gene mutations

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Keywords

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