Anticipation of onset age in familial Parkinson's disease without SCA gene mutations

Yue Huang, Michael Hayes, Antony J. Harding, William S. Brooks, Victor S.C. Fung, Dominic Rowe, Ron Joffe, Denis Crimmins, Mariese Hely, Glenda M. Halliday*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Assessment of a series of 279 cases with Lewy body disease revealed 14 families having a family history consistent with autosomal dominant inheritance, eight of these with dominant Parkinsonism and six with dominant dementia. Analysis of the age at onset and genetic features in these families revealed significant anticipation only in a subset of parkinsonian families, with no pathological alleles for spinocerebellar ataxias or the common α-synuclein or LRRK2 point mutations.

Original languageEnglish
Pages (from-to)309-313
Number of pages5
JournalParkinsonism and Related Disorders
Issue number5
Publication statusPublished - Jun 2006
Externally publishedYes


  • Anticipation
  • Autosomal dominant inheritance
  • Dementia with Lewy bodies
  • Parkinson's disease

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