Antimicrobial, antileishmanial and cytotoxic compounds from Piper chaba

Tarannum Naz, Ashik Mosaddik, Md Motiur Rahman, Ilias Muhammad, Md Ekramul Haque, Somi Kim Cho*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

The petroleum ether and chloroform extracts of the root of Piper chaba showed antimicrobial, antileishmanial and cytotoxic activities. Further bioactivity-guided fractionation led to the isolation of Bornyl piperate (1), piperlonguminine (2) and piperine (3). This is the first report of isolation of compounds (1) and (2) from P. chaba. It was observed that the isolated compounds (1 and 2) showed potent antifungal activity when compared with standard drug Nystatin, and significant cytotoxic activity with the IC 50 values of 0.76 and 0.83 μg mL -1, respectively. These compounds were also found to have weak antibacterial and antileishmanial activities. This is the first report about the antileishmanial activity of Piper isolates.

Original languageEnglish
Pages (from-to)979-986
Number of pages8
JournalNatural Product Research
Volume26
Issue number11
DOIs
Publication statusPublished - 1 Jun 2012

Keywords

  • Antileishmanial
  • Antimicrobial
  • Cytotoxicity
  • Piper chaba

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