Antimicrobial ionic liquid-based materials for biomedical applications

Nasser Nikfarjam, Matineh Ghomi, Tarun Agarwal, Mahnaz Hassanpour, Esmaeel Sharifi, Danial Khorsandi, Moonis Ali Khan, Filippo Rossi, Arianna Rossetti, Ehsan Nazarzadeh Zare, Navid Rabiee, Davoud Afshar, Massoud Vosough, Tapas Kumar Maiti, Virgilio Mattoli, Eric Lichtfouse*, Franklin R. Tay*, Pooyan Makvandi*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Excessive and unwarranted administration of antibiotics has invigorated the evolution of multidrug-resistant microbes. There is, therefore, an urgent need for advanced active compounds. Ionic liquids with short-lived ion-pair structures are highly tunable and have diverse applications. Apart from their unique physicochemical features, the newly discovered biological activities of ionic liquids have fascinated biochemists, microbiologists, and medical scientists. In particular, their antimicrobial properties have opened new vistas in overcoming the current challenges associated with combating antibiotic-resistant pathogens. Discussions regarding ionic liquid derivatives in monomeric and polymeric forms with antimicrobial activities are presented here. The antimicrobial mechanism of ionic liquids and parameters that affect their antimicrobial activities, such as chain length, cation/anion type, cation density, and polymerization, are considered. The potential applications of ionic liquids in the biomedical arena, including regenerative medicine, biosensing, and drug/biomolecule delivery, are presented to stimulate the scientific community to further improve the antimicrobial efficacy of ionic liquids.

Original languageEnglish
JournalAdvanced Functional Materials
Publication statusE-pub ahead of print - 23 Jul 2021
Externally publishedYes


  • antibacterial mechanism
  • chain length
  • drug delivery
  • imidazolium
  • ionic liquid
  • quaternary ammonium
  • tissue regeneration


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