Antinociceptive, antidiarrhoeal and cytotoxic activities of Lagerstroemia speciosa (L.) pers

Md. Atiqur Rahman, Nazim Uddin, Md. Hasanuzzaman, A. A. Rahman

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The ethanol extract of the dried fruits of Lagerstroemia speciosa (L.) Pers. (Family - Lythraceae) was investigated for its possible antinociceptive, antidiarrhoeal and cytotoxic activities in animal models. The extract produced significant (P<0.001) writhing inhibition in acetic acid-induced writhing in mice at the oral dose of 250 and 500 mg/kg of body weight comparable to the standard drug diclofenac sodium at the dose of 25 mg/kg of body weight. The extract showed antidiarrhoeal activity on castor oil induced diarrhoea in mice, it increased mean latent period and decreased the frequency of defecation significantly (P<0.001, P<0.01) at the oral dose of 500 mg/kg body weight comparable to the standard drug Loperamide at the dose of 50 mg/kg of body weight. The crude extract also produced the most prominent cytotoxic activity against brine shrimp Artemia salina (LC50 = 60 μg/ml and LC90 = 100 μg/ml). The obtained results provide a support for the use of this plant in traditional medicine and its further investigation.

Original languageEnglish
Pages (from-to)604-612
Number of pages9
JournalPharmacologyonline
Volume2011
Issue number1
Publication statusPublished - 2011
Externally publishedYes

Keywords

  • antinociceptive activity
  • antidiarrhoel activity
  • cytotoxic activity
  • Lagerstroemia speciosa (L.) pers

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