Antinociceptive, cytotoxic and antibacterial activities of Cleome viscosa leaves

Utpal Bose*, Vaskor Bala, Tarak Nath Ghosh, Karthikeyan Gunasekaran, Ahmed Ayedur Rahman

*Corresponding author for this work

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The methanol extract of the dried leaves of Cleome viscosa L., Cleomaceae, was investigated for its possible antinociceptive, cytotoxic and antibacterial activities in animal models. The extract produced significant writhing inhibition in acetic acid-induced writhing in mice at the oral doses of 250 and 500 mg/kg body weight (p<0.001) comparable to the standard drug diclofenac sodium at the dose of 25 mg/kg of body weight (p<0.001). The crude extract produced the most prominent cytotoxic activity against brine shrimp Artemia salina (LC50 28.18 μg/mL and LC90 112.20 μg/mL). The extract of C. viscosa L. exhibited significant in vitro antibacterial activity against Staphylococcus saprophyticus, Shigella sonnie, Salmonella typhi, Vibrio cholera, Streptococcus epidermidis, Shigella flexneri and Staphylococcus aureus with the zones of inhibition ranging from 10.76 to 16.34 mm. The obtained results provide a support for the use of this plant in traditional medicine and its further investigation.

Original languageEnglish
Pages (from-to)165-169
Number of pages5
JournalBrazilian Journal of Pharmacognosy
Volume21
Issue number1
DOIs
Publication statusPublished - Jan 2011
Externally publishedYes

Keywords

  • antinociceptive
  • cytotoxic
  • antibacterial
  • Cleome viscosa
  • Capparidaceae

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