Antioxidant activities of chitosans and its derivatives in in vitro and in vivo studies

Makoto Anraku*, Janusz M. Gebicki, Daisuke Iohara, Hisao Tomida, Kaneto Uekama, Toru Maruyama, Fumitoshi Hirayama, Masaki Otagiri

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    118 Citations (Scopus)


    This review focuses on the in vitro and in vivo antioxidant activities of various chitosan preparations, including those with different molecular weights and degrees of acetylation and the nanofibers produced from them. In in vitro studies, low molecular weight (LMW) chitosan with high degrees of deacetylation has more potent antioxidant properties than those of high molecular weight (HMW) chitosan. On the other hand, HMW chitosan has higher adsorption properties than those of LMW chitosan. On the basis of the in vitro results obtained, the ingestion of chitosan and nanofiber derived from it, with moderate MW and degrees of acetylation results in a significant reduction in oxidative stress in several chronic oxidative stress related diseases such as the metabolic syndrome and renal failure. In the future, chitosan and related nanofibers with presumed antioxidant properties may be used as a new source of antioxidant, as a possible food supplement, as an ingredient or in the pharmaceutical industry.

    Original languageEnglish
    Pages (from-to)141-149
    Number of pages9
    JournalCarbohydrate Polymers
    Publication statusPublished - 1 Nov 2018


    • chitosan
    • antioxidant
    • renal failure
    • oxidative stress
    • nanofibers


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