Antioxidants and lipid peroxidation status in diabetic patients with and without complications

Rama Srivatsan; Sujata Das; Ranjita Gadde; Krishna Manoj-Kumar; Snigdha Taduri; Nageshwara Rao; B. Ramesh; Akanksha Baharani; Kaajal Shah; Srilakshmi C. Kamireddy; G. Priyatham; T. A. Balakumaran; Shubha Seshadri; Asha Kamath; Anjali Rao

Antioxidants and lipid peroxidation status in diabetic patients with and without complications

Rama Srivatsan, Sujata Das, Ranjita Gadde, Krishna Manoj-Kumar, Snigdha Taduri, Nageshwara Rao, B. Ramesh, Akanksha Baharani, Kaajal Shah, Srilakshmi C. Kamireddy, G. Priyatham, T. A. Balakumaran, Shubha Seshadri, Asha Kamath, Anjali Rao^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

Abstract

Background: Oxidative stress is involved in the pathophysiology of diabetes mellitus.

Methods: In the present study, 68 patients with type 2 diabetes mellitus and 31 clinically healthy individuals were evaluated. The patients were divided into two groups. Group 1 included 29 patients without diabetic complications and group 2 consisted of 39 patients with diabetic complications. Erythrocyte glutathione, superoxide dismutase, and thiobarbituric acid-reactive substance levels as well as plasma antioxidant vitamins C and E, and serum total glutathione-S-transferase, ceruloplasmin, and protein thiols were estimated by using spectrophotometer.

Results: A significant decrease of erythrocyte glutathione was observed in group 1 when compared with the controls. Thiols decreased in group 2. An increase in glutathione-S-transferase, ceruloplasmin, superoxide dismutase, and vitamins C and E levels was noted in patients with diabetes mellitus. Thiobarbituric acid-reactive substance levels decreased in group 1 but increased in group 2 when compared with the controls.

Conclusion: in the present study, tendency of most of the antioxidants to rise in diabetes could probably be due to an adaptive response to the pro-oxidant milieu of the diabetic state. Hence, we suggest that supplementation with dietary antioxidants especially antioxidant vitamins accompanied by change in lifestyle might help to reduce damage brought about by free radical toxicity in diabetes mellitus.

Original language	English
Pages (from-to)	121-127
Number of pages	7
Journal	Archives of Iranian Medicine
Volume	12
Issue number	2
Publication status	Published - Mar 2009
Externally published	Yes

Keywords

Antioxidant
diabetic complications
lipid peroxidation
protein oxidation
GLUTATHIONE-S-TRANSFERASE
OXIDATIVE STRESS
SUPEROXIDE-DISMUTASE
MELLITUS
BLOOD
CERULOPLASMIN
SERUM
POPULATION
NEUROPATHY
ENZYMES

Cite this

Srivatsan, Rama ; Das, Sujata ; Gadde, Ranjita ; Manoj-Kumar, Krishna ; Taduri, Snigdha ; Rao, Nageshwara ; Ramesh, B. ; Baharani, Akanksha ; Shah, Kaajal ; Kamireddy, Srilakshmi C. ; Priyatham, G. ; Balakumaran, T. A. ; Seshadri, Shubha ; Kamath, Asha ; Rao, Anjali. / Antioxidants and lipid peroxidation status in diabetic patients with and without complications. In: Archives of Iranian Medicine. 2009 ; Vol. 12, No. 2. pp. 121-127.

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title = "Antioxidants and lipid peroxidation status in diabetic patients with and without complications",

abstract = "Background: Oxidative stress is involved in the pathophysiology of diabetes mellitus.Methods: In the present study, 68 patients with type 2 diabetes mellitus and 31 clinically healthy individuals were evaluated. The patients were divided into two groups. Group 1 included 29 patients without diabetic complications and group 2 consisted of 39 patients with diabetic complications. Erythrocyte glutathione, superoxide dismutase, and thiobarbituric acid-reactive substance levels as well as plasma antioxidant vitamins C and E, and serum total glutathione-S-transferase, ceruloplasmin, and protein thiols were estimated by using spectrophotometer.Results: A significant decrease of erythrocyte glutathione was observed in group 1 when compared with the controls. Thiols decreased in group 2. An increase in glutathione-S-transferase, ceruloplasmin, superoxide dismutase, and vitamins C and E levels was noted in patients with diabetes mellitus. Thiobarbituric acid-reactive substance levels decreased in group 1 but increased in group 2 when compared with the controls.Conclusion: in the present study, tendency of most of the antioxidants to rise in diabetes could probably be due to an adaptive response to the pro-oxidant milieu of the diabetic state. Hence, we suggest that supplementation with dietary antioxidants especially antioxidant vitamins accompanied by change in lifestyle might help to reduce damage brought about by free radical toxicity in diabetes mellitus.",

keywords = "Antioxidant, diabetic complications, lipid peroxidation, protein oxidation, GLUTATHIONE-S-TRANSFERASE, OXIDATIVE STRESS, SUPEROXIDE-DISMUTASE, MELLITUS, BLOOD, CERULOPLASMIN, SERUM, POPULATION, NEUROPATHY, ENZYMES",

author = "Rama Srivatsan and Sujata Das and Ranjita Gadde and Krishna Manoj-Kumar and Snigdha Taduri and Nageshwara Rao and B. Ramesh and Akanksha Baharani and Kaajal Shah and Kamireddy, {Srilakshmi C.} and G. Priyatham and Balakumaran, {T. A.} and Shubha Seshadri and Asha Kamath and Anjali Rao",

year = "2009",

month = mar,

language = "English",

volume = "12",

pages = "121--127",

journal = "Archives of Iranian Medicine",

issn = "1029-2977",

publisher = "ACAD MEDICAL SCIENCES I R IRAN",

number = "2",

}

Antioxidants and lipid peroxidation status in diabetic patients with and without complications. / Srivatsan, Rama; Das, Sujata; Gadde, Ranjita; Manoj-Kumar, Krishna; Taduri, Snigdha; Rao, Nageshwara; Ramesh, B.; Baharani, Akanksha; Shah, Kaajal; Kamireddy, Srilakshmi C.; Priyatham, G.; Balakumaran, T. A.; Seshadri, Shubha; Kamath, Asha; Rao, Anjali.

In: Archives of Iranian Medicine, Vol. 12, No. 2, 03.2009, p. 121-127.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Antioxidants and lipid peroxidation status in diabetic patients with and without complications

AU - Srivatsan, Rama

AU - Das, Sujata

AU - Gadde, Ranjita

AU - Manoj-Kumar, Krishna

AU - Taduri, Snigdha

AU - Rao, Nageshwara

AU - Ramesh, B.

AU - Baharani, Akanksha

AU - Shah, Kaajal

AU - Kamireddy, Srilakshmi C.

AU - Priyatham, G.

AU - Balakumaran, T. A.

AU - Seshadri, Shubha

AU - Kamath, Asha

AU - Rao, Anjali

PY - 2009/3

Y1 - 2009/3

N2 - Background: Oxidative stress is involved in the pathophysiology of diabetes mellitus.Methods: In the present study, 68 patients with type 2 diabetes mellitus and 31 clinically healthy individuals were evaluated. The patients were divided into two groups. Group 1 included 29 patients without diabetic complications and group 2 consisted of 39 patients with diabetic complications. Erythrocyte glutathione, superoxide dismutase, and thiobarbituric acid-reactive substance levels as well as plasma antioxidant vitamins C and E, and serum total glutathione-S-transferase, ceruloplasmin, and protein thiols were estimated by using spectrophotometer.Results: A significant decrease of erythrocyte glutathione was observed in group 1 when compared with the controls. Thiols decreased in group 2. An increase in glutathione-S-transferase, ceruloplasmin, superoxide dismutase, and vitamins C and E levels was noted in patients with diabetes mellitus. Thiobarbituric acid-reactive substance levels decreased in group 1 but increased in group 2 when compared with the controls.Conclusion: in the present study, tendency of most of the antioxidants to rise in diabetes could probably be due to an adaptive response to the pro-oxidant milieu of the diabetic state. Hence, we suggest that supplementation with dietary antioxidants especially antioxidant vitamins accompanied by change in lifestyle might help to reduce damage brought about by free radical toxicity in diabetes mellitus.

AB - Background: Oxidative stress is involved in the pathophysiology of diabetes mellitus.Methods: In the present study, 68 patients with type 2 diabetes mellitus and 31 clinically healthy individuals were evaluated. The patients were divided into two groups. Group 1 included 29 patients without diabetic complications and group 2 consisted of 39 patients with diabetic complications. Erythrocyte glutathione, superoxide dismutase, and thiobarbituric acid-reactive substance levels as well as plasma antioxidant vitamins C and E, and serum total glutathione-S-transferase, ceruloplasmin, and protein thiols were estimated by using spectrophotometer.Results: A significant decrease of erythrocyte glutathione was observed in group 1 when compared with the controls. Thiols decreased in group 2. An increase in glutathione-S-transferase, ceruloplasmin, superoxide dismutase, and vitamins C and E levels was noted in patients with diabetes mellitus. Thiobarbituric acid-reactive substance levels decreased in group 1 but increased in group 2 when compared with the controls.Conclusion: in the present study, tendency of most of the antioxidants to rise in diabetes could probably be due to an adaptive response to the pro-oxidant milieu of the diabetic state. Hence, we suggest that supplementation with dietary antioxidants especially antioxidant vitamins accompanied by change in lifestyle might help to reduce damage brought about by free radical toxicity in diabetes mellitus.

KW - Antioxidant

KW - diabetic complications

KW - lipid peroxidation

KW - protein oxidation

KW - GLUTATHIONE-S-TRANSFERASE

KW - OXIDATIVE STRESS

KW - SUPEROXIDE-DISMUTASE

KW - MELLITUS

KW - BLOOD

KW - CERULOPLASMIN

KW - SERUM

KW - POPULATION

KW - NEUROPATHY

KW - ENZYMES

M3 - Article

VL - 12

SP - 121

EP - 127

JO - Archives of Iranian Medicine

JF - Archives of Iranian Medicine

SN - 1029-2977

IS - 2

ER -

Antioxidants and lipid peroxidation status in diabetic patients with and without complications

Abstract

Keywords

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