TY - JOUR
T1 - Anxiety symptoms, cerebral amyloid burden and memory decline in healthy older adults without dementia
T2 - 3-year prospective cohort study
AU - Pietrzak, Robert H.
AU - Scott, J. Cobb
AU - Neumeister, Alexander
AU - Lim, Yen Ying
AU - Ames, David
AU - Ellis, Kathryn A.
AU - Harrington, Karra
AU - Lautenschlager, Nicola T.
AU - Szoeke, Cassandra
AU - Martins, Ralph N.
AU - Masters, Colin L.
AU - Villemagne, Victor L.
AU - Rowe, Christopher C.
AU - Maruff, Paul
PY - 2014/5
Y1 - 2014/5
N2 - Although beta-amyloid, anxiety and depression have been linked cross-sectionally to reduced memory function in healthy older adults without dementia, prospective data evaluating these associations are lacking. Using data from an observational cohort study of 178 healthy older adults without dementia followed for 3 years, we found that anxiety symptoms significantly moderated the relationship between beta-amyloid level and decline in verbal (Cohen's d = 0.65) and episodic (Cohen's d = 0.38) memory. Anxiety symptoms were additionally linked to greater decline in executive function, irrespective of beta-amyloid and other risk factors. These findings suggest that interventions to mitigate anxiety symptoms may help delay memory decline in otherwise healthy older adults with elevated beta-amyloid.
AB - Although beta-amyloid, anxiety and depression have been linked cross-sectionally to reduced memory function in healthy older adults without dementia, prospective data evaluating these associations are lacking. Using data from an observational cohort study of 178 healthy older adults without dementia followed for 3 years, we found that anxiety symptoms significantly moderated the relationship between beta-amyloid level and decline in verbal (Cohen's d = 0.65) and episodic (Cohen's d = 0.38) memory. Anxiety symptoms were additionally linked to greater decline in executive function, irrespective of beta-amyloid and other risk factors. These findings suggest that interventions to mitigate anxiety symptoms may help delay memory decline in otherwise healthy older adults with elevated beta-amyloid.
UR - http://www.scopus.com/inward/record.url?scp=84899735109&partnerID=8YFLogxK
UR - http://ulrichsweb.serialssolutions.com/title/1504240003056/36831
U2 - 10.1192/bjp.bp.113.134239
DO - 10.1192/bjp.bp.113.134239
M3 - Article
C2 - 24526746
AN - SCOPUS:84899735109
SN - 0007-1250
VL - 204
SP - 400
EP - 401
JO - British Journal of Psychiatry
JF - British Journal of Psychiatry
IS - 5
ER -