APC as a mobile scaffold

Regulation and function at the nucleus, centrosomes, and mitochondria

Christina Lui, Kate Mills, Mariana G. Brocardo, Manisha Sharma, Beric R. Henderson*

*Corresponding author for this work

Research output: Contribution to journalReview article

21 Citations (Scopus)

Abstract

Genetic mutations of adenomatous polyposis coli (APC) predispose to high risk of human colon cancer. APC is a large tumor suppressor protein and truncating mutations disrupt its normal roles in regulating cell migration, DNA replication/repair, mitosis, apoptosis, and turnover of oncogenic β-catenin. APC is targeted to multiple subcellular sites, and here we discuss recent evidence implicating novel protein interactions and functions of APC in the nucleus and at centrosomes and mitochondria. The ability of APC to shuttle between these and other cell locations is hypothesized to be integral to its cellular function.

Original languageEnglish
Pages (from-to)209-214
Number of pages6
JournalIUBMB Life
Volume64
Issue number3
DOIs
Publication statusPublished - Mar 2012
Externally publishedYes

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