APC shuttling to the membrane, nucleus and beyond

Mariana Brocardo*, Beric R. Henderson

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

68 Citations (Scopus)

Abstract

The adenomatous polyposis coli (APC) tumor suppressor is a multi-functional protein, the mutation of which triggers colon cancer progression through de-regulation of the canonical Wnt signaling pathway and disruption of the mitotic spindle checkpoint. In recent years, APC has been detected at several unexpected intracellular locations, implicating APC in multiple roles that now include the regulation of directed cell migration, apoptosis and DNA repair. In this review, we discuss the intracellular trafficking pathway of APC and describe how truncated cancer-mutant forms of APC display frequent changes in sub-cellular localization and function. The transport routes of APC overlap that of other tumor suppressors, including BRCA1 and p53, pin-pointing common destinations and functions for these cancer regulators.

Original languageEnglish
Pages (from-to)587-596
Number of pages10
JournalTrends in Cell Biology
Volume18
Issue number12
DOIs
Publication statusPublished - Dec 2008
Externally publishedYes

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