Application of microfluidic technology in cancer research and therapy

Shohreh Azadi, Hamidreza Aboulkheyr Es, Arutha Kulasinghe, Pritam Bordhan, Majid Ebrahimi Warkiani*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

3 Citations (Scopus)

Abstract

Cancer is a heterogeneous disease that requires a multimodal approach to diagnose, manage and treat. A better understanding of the disease biology can lead to identification of novel diagnostic/prognostic biomarkers and the discovery of the novel therapeutics with the goal of improving patient outcomes. Employing advanced technologies can facilitate this, enabling better diagnostic and treatment for cancer patients. In this regard, microfluidic technology has emerged as a promising tool in the studies of cancer, including single cancer cell analysis, modeling angiogenesis and metastasis, drug screening and liquid biopsy. Microfluidic technologies have opened new ways to study tumors in the preclinical and clinical settings. In this chapter, we highlight novel application of this technology in area of fundamental, translational and clinical cancer research.

Original languageEnglish
Title of host publicationAdvances in clinical chemistry
EditorsGregory S. Makowski
Place of PublicationCambridge, US ; San Diego, US ; Oxford, UK ; London, UK
PublisherAcademic Press
Chapter5
Pages193-235
Number of pages43
Volume99
ISBN (Electronic)9780128215616
ISBN (Print)9780128215609
DOIs
Publication statusPublished - 2020

Publication series

NameAdvances in Clinical Chemistry
Volume99
ISSN (Print)0065-2423

Keywords

  • Cancer biology
  • Liquid biopsy
  • Microfluidics
  • Precision medicine
  • Tumor-on-a-chip

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