Applications of pharmacogenetics in children with attention-deficit/hyperactivity disorder

Florence Levy*

*Corresponding author for this work

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

This review examines molecular genetic studies shown to be of importance in the etiology of attention-deficit/hyperactivity disorder (ADHD) and contrasts prefrontal versus subcortical mechanisms. Although these mechanisms are not completely dissociated, an understanding of prefrontal dopaminergic/noradrenergic versus subcortical D1/D2 receptor mechanisms is useful for studies of diagnosis versus potential adverse effects. Dopamine physiology, dopamine receptor studies, alpha-2 agonist studies, and dopamine transporter and potential new therapies are reviewed. Further understandings of molecular mechanisms involved in etiology versus treatment and adverse effects should help personalize the treatment of ADHD.

Original languageEnglish
Pages (from-to)349-356
Number of pages8
JournalPharmacogenomics and Personalized Medicine
Volume7
DOIs
Publication statusPublished - 6 Nov 2014
Externally publishedYes

Keywords

  • ADHD
  • Alpha-2 agonists
  • COMT
  • Dopamine receptors
  • Dopamine transporter
  • Stimulant side effects

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