Applications of yeast synthetic biology geared towards the production of biopharmaceuticals

Research output: Contribution to journalReview articleResearchpeer-review

Abstract

Engineered yeast are an important production platform for the biosynthesis of high-value compounds with medical applications. Recent years have witnessed several new developments in this area, largely spurred by advances in the field of synthetic biology and the elucidation of natural metabolic pathways. This minireview presents an overview of synthetic biology applications for the heterologous biosynthesis of biopharmaceuticals in yeast and demonstrates the power and potential of yeast cell factories by highlighting several recent examples. In addition, an outline of emerging trends in this rapidly-developing area is discussed, hinting upon the potential state-of-the-art in the years ahead.

LanguageEnglish
Article number340
Pages1-22
Number of pages22
JournalGenes
Volume9
Issue number7
DOIs
Publication statusPublished - Jul 2018

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Synthetic Biology
Yeasts
Metabolic Networks and Pathways

Bibliographical note

Copyright the Author(s) 2018. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Cite this

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title = "Applications of yeast synthetic biology geared towards the production of biopharmaceuticals",
abstract = "Engineered yeast are an important production platform for the biosynthesis of high-value compounds with medical applications. Recent years have witnessed several new developments in this area, largely spurred by advances in the field of synthetic biology and the elucidation of natural metabolic pathways. This minireview presents an overview of synthetic biology applications for the heterologous biosynthesis of biopharmaceuticals in yeast and demonstrates the power and potential of yeast cell factories by highlighting several recent examples. In addition, an outline of emerging trends in this rapidly-developing area is discussed, hinting upon the potential state-of-the-art in the years ahead.",
keywords = "biopharmaceuticals, biologics, natural products, recombinant proteins, Saccharomy cescerevisiae, synthetic biology, yeast",
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Applications of yeast synthetic biology geared towards the production of biopharmaceuticals. / Walker, Roy S. K.; Pretorius, Isak S.

In: Genes, Vol. 9, No. 7, 340, 07.2018, p. 1-22.

Research output: Contribution to journalReview articleResearchpeer-review

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AU - Pretorius,Isak S.

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