Applications of yeast synthetic biology geared towards the production of biopharmaceuticals

Roy S. K. Walker*, Isak S. Pretorius

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

34 Citations (Scopus)
491 Downloads (Pure)


Engineered yeast are an important production platform for the biosynthesis of high-value compounds with medical applications. Recent years have witnessed several new developments in this area, largely spurred by advances in the field of synthetic biology and the elucidation of natural metabolic pathways. This minireview presents an overview of synthetic biology applications for the heterologous biosynthesis of biopharmaceuticals in yeast and demonstrates the power and potential of yeast cell factories by highlighting several recent examples. In addition, an outline of emerging trends in this rapidly-developing area is discussed, hinting upon the potential state-of-the-art in the years ahead.

Original languageEnglish
Article number340
Pages (from-to)1-22
Number of pages22
Issue number7
Publication statusPublished - Jul 2018

Bibliographical note

Copyright the Author(s) 2018. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.


  • biopharmaceuticals
  • biologics
  • natural products
  • recombinant proteins
  • Saccharomy cescerevisiae
  • synthetic biology
  • yeast


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