Are diet-prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-1 and IGFBP-3 in healthy middle-aged men

D. Gunnell*, S. E. Oliver, T. J. Peters, J. L. Donovan, R. Persad, M. Maynard, D. Gillatt, A. Pearce, F. C. Hamdy, D. E. Neal, J. M P Holly

*Corresponding author for this work

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

We examined the association of diet with insulin-like growth factors (IGF) in 344 disease-free men. Raised levels of IGF-1 and/or its molar ratio with IGFBP-3 were associated with higher intakes of milk, dairy products, calcium, carbohydrate and polyunsaturated fat; lower levels with high vegetable consumption, particularly tomatoes. These patterns support the possibility that IGFs may mediate some diet-cancer associations.

Original languageEnglish
Pages (from-to)1682-1686
Number of pages5
JournalBritish Journal of Cancer
Volume88
Issue number11
DOIs
Publication statusPublished - 2 Jun 2003
Externally publishedYes

Keywords

  • Diet
  • Epidemiology
  • IGF-1
  • IGFBP-3
  • Prostate cancer

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