Are manic symptoms that 'dip' into depression the essence of mixed features?

Gin S. Malhi*, Kristina Fritz, Christine Allwang, Nicole Burston, Chris Cocks, Jill Devlin, Margaret Harper, Ben Hoadley, Brian Kearney, Peter Klug, Linton Meagher, Mark Rowe, Hany Samir, Raymond Way, Craig Wilson, William Lyndon

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


Background Three symptoms of (hypo)mania that clinically represent mood disorders mixed states have been omitted from the DSM-5 mixed features specifier because 'they fail to discriminate between manic and depressive syndromes'. Therefore, the present study examined the role of distractibility, irritability and psychomotor agitation (DIP) in characterising mixed depressive states. Methods Fifty in-patients at a specialist mood disorders unit underwent a detailed longitudinal clinical evaluation (3-6 weeks) and were assessed on a range of standardized measures to characterise their illness according to depression subtype, duration of illness and clinical features-including specifically depressive and manic symptoms and the context in which these occur. Results 49 patients met criteria for major depressive episode, and of these, 34 experienced at least one dip symptom. Patients who endorsed distractibility were more likely to be diagnosed with Bipolar Disorder than Major Depressive Disorder; patients who endorsed irritable mood were more likely to have non-melancholic depression (admixture of depressive and anxiety symptoms), and patients who reported psychomotor agitation experienced a significantly greater number of distinct periods of (hypo)manic symptoms compared with those who did not. Limitations The present study used a modest sample size and did not control for medication or comorbid illness. Although this is inevitable when examining real-world patients in a naturalistic setting, future research needs to allow for comorbidity and its impact, specifically anxiety. Conclusions The present findings suggest that all 3 symptoms that have been excluded from DSM-5 may be cardinal features of mixed states, as they 'dip' into depressive symptoms to create a mixed state.

Original languageEnglish
Pages (from-to)104-108
Number of pages5
JournalJournal of Affective Disorders
Publication statusPublished - 1 Mar 2016
Externally publishedYes


  • Bipolar disorder
  • Distractibility
  • DSM-5
  • Irritability
  • Mixed states
  • Psychomotor agitation


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