Arginine vasopressin (AVP)

a review of its historical perspectives, current research and multifunctional role in the hypothalamo-hypophysial system

Fabio Rotondo*, Henriett Butz, Luis V. Syro, George M. Yousef, Antonio Di Ieva, Lina M. Restrepo, Andres Quintanar-Stephano, Istvan Berczi, Kalman Kovacs

*Corresponding author for this work

Research output: Contribution to journalReview article

26 Citations (Scopus)


Introduction: This publication reviews the function of arginine vasopressin and focuses on the morphologic and functional correlation between the hormone and its effect on stress, the hypophysial–adrenocortical axis, neuroimmune responses, renal function and corticotroph pituitary tumors. Materials and methods: A literature review was performed using various search engines for information regarding the morphology and the multifunctional role of arginine vasopressin. Results: Although a large number of studies were published discussing these interactions, there are several important areas that are still obscure. Conclusion: The questions of how does arginine vasopressin affect the morphology and function of these various areas, and how does the secretion of ACTH and adrenocortical hormones influence the morphology of arginine vasopressin-producing cells and their hormone secretion requires further investigation.

Original languageEnglish
Pages (from-to)345-355
Number of pages11
Issue number4
Publication statusPublished - 1 Aug 2016



  • Arginine vasopressin
  • Corticotroph cells
  • Hypothalamus
  • Pituitary
  • Receptors

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