Armenian hamster female protein (serum amyloid P component). Comparison with the sex-regulated homolog in Syrian hamster

S. B. Dowton*, D. J. Waggoner

*Corresponding author for this work

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Complementary DNA clones for Armenian hamster female protein (FP) were isolated and the complete nucleotide sequence and derived amino acid sequence were determined and compared with relevant data for the closely related Syrian hamster. Although biosynthesis of preSAP is directed by a 1.0-kb mRNA in both genera and the molecular mass of the primary translation product of FP is identical, the FP gene structure and regulation of expression of FP are different in Syrian and Armenian hamsters. Whereas the direction of alteration in FP mRNA levels is divergent in Syrian hamsters during an acute phase reaction, hepatic FP mRNA levels increase in both male and female Armenian hamsters during inflammation. Regulation of expression of Armenian and Syrian hamster FP genes occurs at a pretranslational level.

Original languageEnglish
Pages (from-to)3776-3780
Number of pages5
JournalJournal of Immunology
Volume143
Issue number11
Publication statusPublished - 1989
Externally publishedYes

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