Arterial oxygen desaturation kinetics during apnea

Ian B. Stewart*, Andrew C. Bulmer, James E. Sharman, Lynne Ridgway

*Corresponding author for this work

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Purpose: To quantify the rate of arterial oxygen desaturation during apnea in freedivers. Methods: Ten freedivers and ten controls undertook five maximal face immersion apneas in 10°C water separated by 2 min of recovery. Electrocardiogram (ECG), blood pressure, and pulse oximetry were recorded continuously. Peripheral blood flow was measured by calf plethysmography every 30 s, and venous blood samples were collected at rest and after apneas 1, 3, and 5. The blood was analyzed for hematocrit (Hct), lactate, and hemoglobin (Hb) concentration. The arterial oxygen saturation (SaO2) data were curve fitted with both a sigmoid and two-slope continuous function. Results: Apnea duration increased with successive attempts, with freedivers achieving significantly longer maximal apneas (trained 246 ± 44 s, untrained 129 ± 39 s, P < 0.001). Compared with controls, freedivers displayed a significant change from baseline in heart rate (trained -27.2 ± 9.5 bpm, untrained -19.7 ± 9.3 bpm, P < 0.001) and mean arterial pressure (MAP) (trained 48 ± 20.7 mm Hg, untrained 37 ± 10.0 mm Hg, P = 0.002), but no difference existed in peripheral blood flow, Hct, lactate, or Hb. The maximal slope of the SaO2 sigmoid curve was not significantly different between the groups (trained -0.16 ± 0.05%·s -1, untrained -0.15 ± 0.06%·s-1, P = 0.26), but the ΔSaO2/Δt obtained from the two-slope continuous model indicated that 85% of the variance in the freedivers ΔSaO 2/At could be explained by the apnea-induced bradycardia, preapnea vital capacity, and Hb concentration. Conclusions: The sigmoidal function provided no quantifiable difference in the rate of oxygen desaturation. The two-slope continuous method, however, indicated that freedivers who had larger oxygen stores and produced the largest bradycardia were able to slow the ΔSaO2/Δt to two to three times that of the least marked response.

Original languageEnglish
Pages (from-to)1871-1876
Number of pages6
JournalMedicine and Science in Sports and Exercise
Volume37
Issue number11
DOIs
Publication statusPublished - Nov 2005
Externally publishedYes

Keywords

  • Arterial oxygen saturation
  • Breath hold
  • Diving response
  • Sigmoid logistic function

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