Arterial pulsation-dependent perivascular cerebrospinal fluid flow into the central canal in the sheep spinal cord

Marcus A. Stoodley*, Sally A. Brown, Christopher J. Brown, Nigel R. Jones

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

96 Citations (Scopus)

Abstract

The impetus for the enlargement of syringes is unknown. The authors hypothesize that there is a flow of cerebrospinal fluid (CSF) from perivascular spaces into the central canal and that the flow is driven by arterial pulsations. Using horseradish peroxidase as a tracer, the CSF flow was studied in normal sheep, in sheep with damped arterial pulsations, and in sheep with lowered spinal subarachnoid pressure. The CSF flow from perivascular spaces into the central canal was demonstrated in the normal sheep, and two patterns of flow were identified: 1) from perivascular spaces in the central gray matter; and 2) from perivascular spaces in the ventral white commissure. Flow into the central canal was also observed in the sheep with lowered spinal subarachnoid pressure, but not in those with reduced arterial pulse pressure. This study provides evidence that CSF flow from perivascular spaces into the central canal is dependent on arterial pulsations. Arterial pulsation-driven CSF flow may be the impetus for the expansion of syringes.

Original languageEnglish
Pages (from-to)686-693
Number of pages8
JournalJournal of Neurosurgery
Volume86
Issue number4
Publication statusPublished - Apr 1997
Externally publishedYes

Keywords

  • arterial pulsations
  • central spinal canal
  • cerebrospinal fluid
  • perivascular space
  • sheep
  • syringomyelia

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