Arterial stiffness and influences of the metabolic syndrome: a cross-countries study

Angelo Scuteri*, Pedro G. Cunha, E. Agabiti Rosei, Jolita Badariere, Sofie Bekaert, John R. Cockcroft, Jorge Cotter, Francesco Cucca, Marc L. De Buyzere, Tim De Meyer, Luigi Ferrucci, Osca Franco, Nichols Gale, Thierry C. Gillebert, A. Hofman, Michel Langlois, Aleksandras Laucevicius, Stephane Laurent, Francesco U. S. Mattace Raso, Cristopher H. MorrellMaria Lorenza Muiesan, Margaret M. Munnery, Rokas Navickas, Pedro Oliveira, Marco Orru', Maria Grazia Pilia, Ernst R. Rietzschel, Ligita Ryliskyte, Massimo Salvetti, David Schlessinger, Nuno Sousa, Christodoulos Stefanadis, James Strait, Caroline Van daele, Isabel Villa, Charalambos Vlachopoulos, Jacqueline Witteman, Panagiotis Xaplanteris, Peter Nilsson, Edward G. Lakatta, Metabolic Syndrome and Arteries Research (MARE) Consortium

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

98 Citations (Scopus)


Specific clusters of metabolic syndrome (MetS) components impact differentially on arterial stiffness, indexed as pulse wave velocity (PWV). Of note, in several population-based studies participating in the MARE (Metabolic syndrome and Arteries REsearch) Consortium the occurrence of specific clusters of MetS differed markedly across Europe and the US. The aim of the present study was to investigate whether specific clusters of MetS are consistently associated with stiffer arteries in different populations. We studied 20,570 subjects from 9 cohorts representing 8 different European countries and the US participating in the MARE Consortium. MetS was defined in accordance with NCEP ATPIII criteria as the simultaneous alteration in ≥3 of the 5 components: abdominal obesity ( W), high triglycerides ( T), low HDL cholesterol ( H), elevated blood pressure ( B), and elevated fasting glucose ( G). PWV measured in each cohort was "normalized" to account for different acquisition methods.MetS had an overall prevalence of 24.2% (4985 subjects). MetS accelerated the age-associated increase in PWV levels at any age, and similarly in men and women. MetS clusters TBW, GBW, and GTBW are consistently associated with significantly stiffer arteries to an extent similar or greater than observed in subjects with alteration in all the five MetS components - even after controlling for age, sex, smoking, cholesterol levels, and diabetes mellitus - in all the MARE cohorts.In conclusion, different component clusters of MetS showed varying associations with arterial stiffness (PWV).

Original languageEnglish
Pages (from-to)654-660
Number of pages7
Issue number2
Publication statusPublished - Apr 2014
Externally publishedYes


  • Arterial stiffness
  • Cross-cultural comparison
  • Metabolic syndrome
  • Pulse wave velocity


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