Abstract
The invention relates to methods and assays for identifying compounds as candidates in the development of a drug for the treatment of various diseases including those associated with pathological Tau. The invention also relates to methods and assays for identifying compounds for the treatment of various diseases including those associated with pathological Tau. The invention also relates to cell lines and constructs for use in an assay of the invention. The methods and assays identify a compound as useful in the treatment of a tauopathy if said compound modulates Sil1 expression or activity.
| Original language | English |
|---|---|
| Patent number | 10634688 |
| IPC | G01N 33/68,C12Q 1/6883 |
| Priority date | 6/03/13 |
| Filing date | 6/03/14 |
| Publication status | Published - 28 Apr 2020 |
Keywords
- tau