Assessing sleep architecture and cognition in older adults with depressive symptoms attending a memory clinic

Andrea Ricciardiello; Andrew C. McKinnon; Loren Mowszowski; Haley M. LaMonica; Zoe Menczel Schrire; Carla Haroutonian; Aaron Lam; Ian B. Hickie; Angela D'Rozario; Sharon L. Naismith

doi:10.1016/j.jad.2023.12.032

Assessing sleep architecture and cognition in older adults with depressive symptoms attending a memory clinic

Andrea Ricciardiello^*, Andrew C. McKinnon, Loren Mowszowski, Haley M. LaMonica, Zoe Menczel Schrire, Carla Haroutonian, Aaron Lam, Ian B. Hickie, Angela D'Rozario, Sharon L. Naismith

^*Corresponding author for this work

School of Psychological Sciences

Research output: Contribution to journal › Article › peer-review

52 Downloads (Pure)

Abstract

BACKGROUND: While depression is intrinsically and bidirectionally linked with both sleep disturbance and cognition, the inter-relationships between sleep, cognition, and brain integrity in older people with depression, especially those with late-onset depression are undefined.

METHODS: One hundred and seventy-two older adults (mean age 64.3 ± 6.9 years, Depression: n = 66, Control: n = 106) attending a memory clinic underwent a neuropsychological battery of declarative memory, executive function tasks, cerebral magnetic resonance imaging and overnight polysomnography with quantitative electroencephalography.

RESULTS: The time spent in slow-wave sleep (SWS) and rapid eye movement (REM) sleep, slow-wave activity, sleep spindles, hippocampal volume and prefrontal cortex thickness did not differ between depression and control and depression onset groups. However, sleep onset latency (p = 0.005) and REM onset latency (p = 0.02) were later in the Depression group compared to controls. Less SWS was associated with poorer memory (r = 0.31, p = 0.023) in the depression group, and less SWS was related to better memory in the control group (r = -0.20, p = 0.043; Fishers r-to-z = -3.19).

LIMITATIONS: Longitudinal studies are needed to determine if changes in sleep in those with depressive symptoms predict cognitive decline and illness trajectory.

CONCLUSION: Older participants with depressive symptoms had delayed sleep initiation, suggestive of delayed sleep phase. The association between SWS and memory suggests SWS may be a useful target for cognitive intervention in older adults with depression symptoms. Reduced hippocampal volumes did not mediate this relationship, indicating a broader distributed neural network may underpin these associations.

Original language	English
Pages (from-to)	35-43
Number of pages	9
Journal	Journal of Affective Disorders
Volume	348
Early online date	18 Dec 2023
DOIs	https://doi.org/10.1016/j.jad.2023.12.032
Publication status	Published - 1 Mar 2024

Bibliographical note

Copyright the Author(s) 2023. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

depression
sleep macro-architecture
sleep micro-architecture
memory
ageing

Access to Document

10.1016/j.jad.2023.12.032Licence: CC BY

Publisher version (open access)Final published version, 5.59 MBLicence: CC BY

Cite this

@article{152417bc15b5498c8eaf0ce45996e4ec,

title = "Assessing sleep architecture and cognition in older adults with depressive symptoms attending a memory clinic",

abstract = "BACKGROUND: While depression is intrinsically and bidirectionally linked with both sleep disturbance and cognition, the inter-relationships between sleep, cognition, and brain integrity in older people with depression, especially those with late-onset depression are undefined.METHODS: One hundred and seventy-two older adults (mean age 64.3 ± 6.9 years, Depression: n = 66, Control: n = 106) attending a memory clinic underwent a neuropsychological battery of declarative memory, executive function tasks, cerebral magnetic resonance imaging and overnight polysomnography with quantitative electroencephalography.RESULTS: The time spent in slow-wave sleep (SWS) and rapid eye movement (REM) sleep, slow-wave activity, sleep spindles, hippocampal volume and prefrontal cortex thickness did not differ between depression and control and depression onset groups. However, sleep onset latency (p = 0.005) and REM onset latency (p = 0.02) were later in the Depression group compared to controls. Less SWS was associated with poorer memory (r = 0.31, p = 0.023) in the depression group, and less SWS was related to better memory in the control group (r = -0.20, p = 0.043; Fishers r-to-z = -3.19).LIMITATIONS: Longitudinal studies are needed to determine if changes in sleep in those with depressive symptoms predict cognitive decline and illness trajectory.CONCLUSION: Older participants with depressive symptoms had delayed sleep initiation, suggestive of delayed sleep phase. The association between SWS and memory suggests SWS may be a useful target for cognitive intervention in older adults with depression symptoms. Reduced hippocampal volumes did not mediate this relationship, indicating a broader distributed neural network may underpin these associations.",

keywords = "depression, sleep macro-architecture, sleep micro-architecture, memory, ageing",

author = "Andrea Ricciardiello and McKinnon, {Andrew C.} and Loren Mowszowski and LaMonica, {Haley M.} and Schrire, {Zoe Menczel} and Carla Haroutonian and Aaron Lam and Hickie, {Ian B.} and Angela D'Rozario and Naismith, {Sharon L.}",

note = "Copyright the Author(s) 2023. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

year = "2024",

month = mar,

day = "1",

doi = "10.1016/j.jad.2023.12.032",

language = "English",

volume = "348",

pages = "35--43",

journal = "Journal of Affective Disorders",

issn = "0165-0327",

publisher = "Elsevier",

}

TY - JOUR

T1 - Assessing sleep architecture and cognition in older adults with depressive symptoms attending a memory clinic

AU - Ricciardiello, Andrea

AU - McKinnon, Andrew C.

AU - Mowszowski, Loren

AU - LaMonica, Haley M.

AU - Schrire, Zoe Menczel

AU - Haroutonian, Carla

AU - Lam, Aaron

AU - Hickie, Ian B.

AU - D'Rozario, Angela

AU - Naismith, Sharon L.

N1 - Copyright the Author(s) 2023. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2024/3/1

Y1 - 2024/3/1

N2 - BACKGROUND: While depression is intrinsically and bidirectionally linked with both sleep disturbance and cognition, the inter-relationships between sleep, cognition, and brain integrity in older people with depression, especially those with late-onset depression are undefined.METHODS: One hundred and seventy-two older adults (mean age 64.3 ± 6.9 years, Depression: n = 66, Control: n = 106) attending a memory clinic underwent a neuropsychological battery of declarative memory, executive function tasks, cerebral magnetic resonance imaging and overnight polysomnography with quantitative electroencephalography.RESULTS: The time spent in slow-wave sleep (SWS) and rapid eye movement (REM) sleep, slow-wave activity, sleep spindles, hippocampal volume and prefrontal cortex thickness did not differ between depression and control and depression onset groups. However, sleep onset latency (p = 0.005) and REM onset latency (p = 0.02) were later in the Depression group compared to controls. Less SWS was associated with poorer memory (r = 0.31, p = 0.023) in the depression group, and less SWS was related to better memory in the control group (r = -0.20, p = 0.043; Fishers r-to-z = -3.19).LIMITATIONS: Longitudinal studies are needed to determine if changes in sleep in those with depressive symptoms predict cognitive decline and illness trajectory.CONCLUSION: Older participants with depressive symptoms had delayed sleep initiation, suggestive of delayed sleep phase. The association between SWS and memory suggests SWS may be a useful target for cognitive intervention in older adults with depression symptoms. Reduced hippocampal volumes did not mediate this relationship, indicating a broader distributed neural network may underpin these associations.

AB - BACKGROUND: While depression is intrinsically and bidirectionally linked with both sleep disturbance and cognition, the inter-relationships between sleep, cognition, and brain integrity in older people with depression, especially those with late-onset depression are undefined.METHODS: One hundred and seventy-two older adults (mean age 64.3 ± 6.9 years, Depression: n = 66, Control: n = 106) attending a memory clinic underwent a neuropsychological battery of declarative memory, executive function tasks, cerebral magnetic resonance imaging and overnight polysomnography with quantitative electroencephalography.RESULTS: The time spent in slow-wave sleep (SWS) and rapid eye movement (REM) sleep, slow-wave activity, sleep spindles, hippocampal volume and prefrontal cortex thickness did not differ between depression and control and depression onset groups. However, sleep onset latency (p = 0.005) and REM onset latency (p = 0.02) were later in the Depression group compared to controls. Less SWS was associated with poorer memory (r = 0.31, p = 0.023) in the depression group, and less SWS was related to better memory in the control group (r = -0.20, p = 0.043; Fishers r-to-z = -3.19).LIMITATIONS: Longitudinal studies are needed to determine if changes in sleep in those with depressive symptoms predict cognitive decline and illness trajectory.CONCLUSION: Older participants with depressive symptoms had delayed sleep initiation, suggestive of delayed sleep phase. The association between SWS and memory suggests SWS may be a useful target for cognitive intervention in older adults with depression symptoms. Reduced hippocampal volumes did not mediate this relationship, indicating a broader distributed neural network may underpin these associations.

KW - depression

KW - sleep macro-architecture

KW - sleep micro-architecture

KW - memory

KW - ageing

UR - http://www.scopus.com/inward/record.url?scp=85180813296&partnerID=8YFLogxK

U2 - 10.1016/j.jad.2023.12.032

DO - 10.1016/j.jad.2023.12.032

M3 - Article

C2 - 38123073

SN - 0165-0327

VL - 348

SP - 35

EP - 43

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

ER -

Assessing sleep architecture and cognition in older adults with depressive symptoms attending a memory clinic

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this