Assessment of amyloid β in pathologically confirmed frontotemporal dementia syndromes

Rachel H. Tan; Jillian J. Kril; Yue Yang; Nicole Tom; John R. Hodges; Victor L. Villemagne; Christopher C. Rowe; Cristian E. Leyton; John B. J. Kwok; Lars M. Ittner; Glenda M. Halliday

doi:10.1016/j.dadm.2017.05.005

Assessment of amyloid β in pathologically confirmed frontotemporal dementia syndromes

Rachel H. Tan^*, Jillian J. Kril, Yue Yang, Nicole Tom, John R. Hodges, Victor L. Villemagne, Christopher C. Rowe, Cristian E. Leyton, John B. J. Kwok, Lars M. Ittner, Glenda M. Halliday

^*Corresponding author for this work

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Abstract

Introduction: The diagnostic utility of in vivo amyloid β (Aβ) imaging to aid in the clinical distinction between frontotemporal dementia (FTD) and Alzheimer's disease remains unclear without data on the prevalence and severity of Aβ in pathologically confirmed FTD syndromes. Methods: Aβ was assessed in 98 autopsy-confirmed FTD and 36 control cases, and the pathological accuracy of ¹¹C-Pittsburgh compound B (PiB)–positron emission tomography imaging was assessed in a subset of FTD cases (n = 15). Results: Aβ was identified in a similar proportion of FTD syndromes and age-matched controls and increases with age. Alzheimer's disease pathology was identified in all cases with high PiB retention and in one case with low PiB retention. We further demonstrate a strong regional correlation between volume fraction of histological Aβ with PiB standard uptake value ratio scaled to the white matter. Discussion: The present study provides a pathologic reference to assist in the interpretation of in vivo assessments in FTD syndromes.

Original language	English
Pages (from-to)	10-20
Number of pages	11
Journal	Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume	9
DOIs	https://doi.org/10.1016/j.dadm.2017.05.005
Publication status	Published - 1 Jan 2017
Externally published	Yes

Bibliographical note

Copyright the Author(s) 2017. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

11C-Pittsburgh compound B
Alzheimer's disease
Amyloid β
Diagnostic
Frontotemporal dementia syndromes

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10.1016/j.dadm.2017.05.005

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Tan, R. H., Kril, J. J., Yang, Y., Tom, N., Hodges, J. R., Villemagne, V. L., Rowe, C. C., Leyton, C. E., Kwok, J. B. J., Ittner, L. M., & Halliday, G. M. (2017). Assessment of amyloid β in pathologically confirmed frontotemporal dementia syndromes. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 9, 10-20. https://doi.org/10.1016/j.dadm.2017.05.005

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abstract = "Introduction: The diagnostic utility of in vivo amyloid β (Aβ) imaging to aid in the clinical distinction between frontotemporal dementia (FTD) and Alzheimer's disease remains unclear without data on the prevalence and severity of Aβ in pathologically confirmed FTD syndromes. Methods: Aβ was assessed in 98 autopsy-confirmed FTD and 36 control cases, and the pathological accuracy of 11C-Pittsburgh compound B (PiB)–positron emission tomography imaging was assessed in a subset of FTD cases (n = 15). Results: Aβ was identified in a similar proportion of FTD syndromes and age-matched controls and increases with age. Alzheimer's disease pathology was identified in all cases with high PiB retention and in one case with low PiB retention. We further demonstrate a strong regional correlation between volume fraction of histological Aβ with PiB standard uptake value ratio scaled to the white matter. Discussion: The present study provides a pathologic reference to assist in the interpretation of in vivo assessments in FTD syndromes.",

keywords = "11C-Pittsburgh compound B, Alzheimer's disease, Amyloid β, Diagnostic, Frontotemporal dementia syndromes",

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doi = "10.1016/j.dadm.2017.05.005",

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AU - Kril, Jillian J.

AU - Yang, Yue

AU - Tom, Nicole

AU - Hodges, John R.

AU - Villemagne, Victor L.

AU - Rowe, Christopher C.

AU - Leyton, Cristian E.

AU - Kwok, John B. J.

AU - Ittner, Lars M.

AU - Halliday, Glenda M.

N1 - Copyright the Author(s) 2017. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Introduction: The diagnostic utility of in vivo amyloid β (Aβ) imaging to aid in the clinical distinction between frontotemporal dementia (FTD) and Alzheimer's disease remains unclear without data on the prevalence and severity of Aβ in pathologically confirmed FTD syndromes. Methods: Aβ was assessed in 98 autopsy-confirmed FTD and 36 control cases, and the pathological accuracy of 11C-Pittsburgh compound B (PiB)–positron emission tomography imaging was assessed in a subset of FTD cases (n = 15). Results: Aβ was identified in a similar proportion of FTD syndromes and age-matched controls and increases with age. Alzheimer's disease pathology was identified in all cases with high PiB retention and in one case with low PiB retention. We further demonstrate a strong regional correlation between volume fraction of histological Aβ with PiB standard uptake value ratio scaled to the white matter. Discussion: The present study provides a pathologic reference to assist in the interpretation of in vivo assessments in FTD syndromes.

AB - Introduction: The diagnostic utility of in vivo amyloid β (Aβ) imaging to aid in the clinical distinction between frontotemporal dementia (FTD) and Alzheimer's disease remains unclear without data on the prevalence and severity of Aβ in pathologically confirmed FTD syndromes. Methods: Aβ was assessed in 98 autopsy-confirmed FTD and 36 control cases, and the pathological accuracy of 11C-Pittsburgh compound B (PiB)–positron emission tomography imaging was assessed in a subset of FTD cases (n = 15). Results: Aβ was identified in a similar proportion of FTD syndromes and age-matched controls and increases with age. Alzheimer's disease pathology was identified in all cases with high PiB retention and in one case with low PiB retention. We further demonstrate a strong regional correlation between volume fraction of histological Aβ with PiB standard uptake value ratio scaled to the white matter. Discussion: The present study provides a pathologic reference to assist in the interpretation of in vivo assessments in FTD syndromes.

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Assessment of amyloid β in pathologically confirmed frontotemporal dementia syndromes

Abstract

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