Assessment of baroreflex sensitivity by continuous noninvasive monitoring of peripheral and central aortic pressure

Zahra Kouchaki, Mark Butlin, Ahmed Qasem, Alberto P. Avolio*

*Corresponding author for this work

    Research output: Chapter in Book/Report/Conference proceedingConference proceeding contribution

    1 Citation (Scopus)

    Abstract

    Noninvasive assessment of baroreceptor sensitivity (BRS) facilitates clinical investigation of autonomic function. The spontaneous sequence method estimates BRS using the continuous measurement of arterial pressure in the finger. Since the baroreceptors are centrally located (aortic arch, carotid arteries), this study assessed the use of a continuous aortic pressure signal derived from the peripheral pressure pulse to compute the BRS from changes in systolic pressure (SBP) and pulse interval (PI). BRS computed from central aortic (cBRS) and peripheral pressure (pBRS) was calculated in 12 healthy subjects (25-62 years, 7 females). The difference between pBRS and cBRS was calculated for four levels of pulse lags between changes in SBP and PI. For each lag and for the pooled data for all lags, cBRS was significantly correlated with pBRS (r2=0.82). The within subject difference ranged from -41.2% to 59.2%. This difference was not related to age, gender of hemodynamic parameters (systolic or diastolic pressure, heart rate, aortic pulse wave velocity). However 18.2% of the variance was due to the difference in the number of spontaneous pulse sequences used to determine values of cBRS and pBRS. The differences between pBRS and cBRS are in the range of values of BRS as those found, in other studies, to discriminate between patient groups with different levels of autonomic function. Findings of this study suggest that, given the heart rate dependent amplification of the arterial pressure pulse between the central aorta and the peripheral limbs, BRS determined from central aortic pressure derived from the peripheral pulse may provide an improved method for noninvasive assessment of baroreceptor function.

    Original languageEnglish
    Title of host publication2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
    Place of PublicationPiscataway, NJ
    PublisherInstitute of Electrical and Electronics Engineers (IEEE)
    Pages2940-2943
    Number of pages4
    ISBN (Electronic)9781424479290
    ISBN (Print)9781424479276
    DOIs
    Publication statusPublished - 2 Nov 2014
    Event2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014 - Chicago, United States
    Duration: 26 Aug 201430 Aug 2014

    Publication series

    NameIEEE Engineering in Medicine and Biology Society. Conference Proceedings
    PublisherInstitute of Electrical and Electronics Engineers
    ISSN (Print)1094-687X
    ISSN (Electronic)1558-4615

    Other

    Other2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
    CountryUnited States
    CityChicago
    Period26/08/1430/08/14

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    Cite this

    Kouchaki, Z., Butlin, M., Qasem, A., & Avolio, A. P. (2014). Assessment of baroreflex sensitivity by continuous noninvasive monitoring of peripheral and central aortic pressure. In 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014 (pp. 2940-2943). [6944239] (IEEE Engineering in Medicine and Biology Society. Conference Proceedings). Piscataway, NJ: Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/EMBC.2014.6944239