Noninvasive assessment of baroreceptor sensitivity (BRS) facilitates clinical investigation of autonomic function. The spontaneous sequence method estimates BRS using the continuous measurement of arterial pressure in the finger. Since the baroreceptors are centrally located (aortic arch, carotid arteries), this study assessed the use of a continuous aortic pressure signal derived from the peripheral pressure pulse to compute the BRS from changes in systolic pressure (SBP) and pulse interval (PI). BRS computed from central aortic (cBRS) and peripheral pressure (pBRS) was calculated in 12 healthy subjects (25-62 years, 7 females). The difference between pBRS and cBRS was calculated for four levels of pulse lags between changes in SBP and PI. For each lag and for the pooled data for all lags, cBRS was significantly correlated with pBRS (r2=0.82). The within subject difference ranged from -41.2% to 59.2%. This difference was not related to age, gender of hemodynamic parameters (systolic or diastolic pressure, heart rate, aortic pulse wave velocity). However 18.2% of the variance was due to the difference in the number of spontaneous pulse sequences used to determine values of cBRS and pBRS. The differences between pBRS and cBRS are in the range of values of BRS as those found, in other studies, to discriminate between patient groups with different levels of autonomic function. Findings of this study suggest that, given the heart rate dependent amplification of the arterial pressure pulse between the central aorta and the peripheral limbs, BRS determined from central aortic pressure derived from the peripheral pulse may provide an improved method for noninvasive assessment of baroreceptor function.