Challenges faced in diagnosis and treatment of drug induced liver injury (DILI) have formed the aim of this project to quantify non-invasive MRI and MRS markers to aide research into future therapeutics of DILI. Using an acetaminophen overdose model, we have managed to quantify 4 different MRI biomarkers: liver volume, T2 mapping, ADC and water/fat ratio. Significant changes were observed with an increase in liver volume and T2 relaxation and water/fat ratio, with a decrease in diffusion coefficient. Some degree of normalization in T2 and ADC values was noted after NAC treatment indicating that MRI and MRS can play an important role in the diagnosis of DILI.
|Publication status||Published - 2017|
|Event||The ISMRM 25th Annual Meeting and Exhibition (2017) - Honolulu, United States|
Duration: 22 Apr 2017 → 27 Apr 2017
|Conference||The ISMRM 25th Annual Meeting and Exhibition (2017)|
|Period||22/04/17 → 27/04/17|