Assessment of novel blood pressure corrected cardio-ankle vascular index in response to acute blood pressure changes

Michal Mestanik; Bart Spronck; Alexander Jurko; Andrea Mestanikova; Tomas Jurko; Mark Butlin; Alberto Avolio; Lucia Bona Olexova; Zuzana Visnovcova; Nikola Sekaninova; Ingrid Tonhajzerova

doi:10.2991/artres.k.191224.158

Abstract

Background: Cardio-ankle vascular index (CAVI) has long been considered a measure of arterial stiffness independent of short-term changes in blood pressure (BP) [1]. Recently and theoretically, CAVI was found to be partially affected by actual BP, thus, a novel BP-corrected index, CAVI0, was proposed to diminish these effects [2,3]. Direct, repeated measures experimental data comparing CAVI’s and CAVI0’s acute blood pressure dependence is lacking. Hence, the aim of this study was to assess the effects of short-term changes of BP on CAVI0 in comparison with standard CAVI.

Methods: 60 healthy adults were examined using vascular screening system VaSera 1500 N (Fukuda Denshi Co., Tokyo, Japan) during four examination periods lasting 5 minutes – baseline, cold pressor test (CPT), recovery period, and isometric handgrip exercise (IHE). CAVI and cardiovascular parameters for calculation of CAVI0 were measured after baseline, at the peak of pressor response to CPT, after recovery period, and at the peak of pressor response to IHE. CAVI, CAVI0, and mean BP were assessed for all periods.

Results: CAVI significantly increased during CPT compared to baseline rest (p = 0.008), returned to baseline values during recovery period (p = 0.011 compared to CPT), and significantly increased during IHE compared to recovery period (p = 0.002). No significant changes of CAVI0 were found. CAVI significantly correlated with changes in mean BP (p = 0.012; multilevel regression); CAVI0 did not (p = 0.570).

Conclusion: In this repeated measures, experimental, acute study, CAVI showed short-term blood pressure dependence, whereas CAVI0 did not.

Original language	English
Article number	P135
Pages (from-to)	S173
Number of pages	1
Journal	Artery Research
Volume	25
Issue number	Supplement 1
DOIs	https://doi.org/10.2991/artres.k.191224.158
Publication status	Published - 2019
Event	Association for Research into Arterial Structure and Physiology Conference 2019: ARTERY 2019 - Budapest, Hungary Duration: 10 Oct 2019 → 12 Oct 2019

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Copyright the Association for Research into Arterial Structure and Physiology 2019. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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Mestanik, M., Spronck, B., Jurko, A., Mestanikova, A., Jurko, T., Butlin, M., Avolio, A., Olexova, L. B., Visnovcova, Z., Sekaninova, N., & Tonhajzerova, I. (2019). Assessment of novel blood pressure corrected cardio-ankle vascular index in response to acute blood pressure changes. Artery Research, 25(Supplement 1), S173. [P135]. https://doi.org/10.2991/artres.k.191224.158

Mestanik, Michal ; Spronck, Bart ; Jurko, Alexander ; Mestanikova, Andrea ; Jurko, Tomas ; Butlin, Mark ; Avolio, Alberto ; Olexova, Lucia Bona ; Visnovcova, Zuzana ; Sekaninova, Nikola ; Tonhajzerova, Ingrid. / Assessment of novel blood pressure corrected cardio-ankle vascular index in response to acute blood pressure changes. In: Artery Research. 2019 ; Vol. 25, No. Supplement 1. pp. S173.

@article{b11e1fe9182c4648a38257734a4e775a,

title = "Assessment of novel blood pressure corrected cardio-ankle vascular index in response to acute blood pressure changes",

abstract = "Background: Cardio-ankle vascular index (CAVI) has long been considered a measure of arterial stiffness independent of short-term changes in blood pressure (BP) [1]. Recently and theoretically, CAVI was found to be partially affected by actual BP, thus, a novel BP-corrected index, CAVI0, was proposed to diminish these effects [2,3]. Direct, repeated measures experimental data comparing CAVI{\textquoteright}s and CAVI0{\textquoteright}s acute blood pressure dependence is lacking. Hence, the aim of this study was to assess the effects of short-term changes of BP on CAVI0 in comparison with standard CAVI.Methods: 60 healthy adults were examined using vascular screening system VaSera 1500 N (Fukuda Denshi Co., Tokyo, Japan) during four examination periods lasting 5 minutes – baseline, cold pressor test (CPT), recovery period, and isometric handgrip exercise (IHE). CAVI and cardiovascular parameters for calculation of CAVI0 were measured after baseline, at the peak of pressor response to CPT, after recovery period, and at the peak of pressor response to IHE. CAVI, CAVI0, and mean BP were assessed for all periods.Results: CAVI significantly increased during CPT compared to baseline rest (p = 0.008), returned to baseline values during recovery period (p = 0.011 compared to CPT), and significantly increased during IHE compared to recovery period (p = 0.002). No significant changes of CAVI0 were found. CAVI significantly correlated with changes in mean BP (p = 0.012; multilevel regression); CAVI0 did not (p = 0.570).Conclusion: In this repeated measures, experimental, acute study, CAVI showed short-term blood pressure dependence, whereas CAVI0 did not.",

author = "Michal Mestanik and Bart Spronck and Alexander Jurko and Andrea Mestanikova and Tomas Jurko and Mark Butlin and Alberto Avolio and Olexova, {Lucia Bona} and Zuzana Visnovcova and Nikola Sekaninova and Ingrid Tonhajzerova",

note = "Copyright the Association for Research into Arterial Structure and Physiology 2019. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.; Association for Research into Arterial Structure and Physiology Conference 2019 : ARTERY 2019 ; Conference date: 10-10-2019 Through 12-10-2019",

year = "2019",

doi = "10.2991/artres.k.191224.158",

language = "English",

volume = "25",

pages = "S173",

journal = "Artery Research",

issn = "1872-9312",

publisher = "Elsevier",

number = "Supplement 1",

}

Mestanik, M, Spronck, B, Jurko, A, Mestanikova, A, Jurko, T, Butlin, M , Avolio, A, Olexova, LB, Visnovcova, Z, Sekaninova, N & Tonhajzerova, I 2019, 'Assessment of novel blood pressure corrected cardio-ankle vascular index in response to acute blood pressure changes', Artery Research, vol. 25, no. Supplement 1, P135, pp. S173. https://doi.org/10.2991/artres.k.191224.158

Assessment of novel blood pressure corrected cardio-ankle vascular index in response to acute blood pressure changes. / Mestanik, Michal; Spronck, Bart; Jurko, Alexander; Mestanikova, Andrea; Jurko, Tomas; Butlin, Mark ; Avolio, Alberto; Olexova, Lucia Bona; Visnovcova, Zuzana; Sekaninova, Nikola; Tonhajzerova, Ingrid.

In: Artery Research, Vol. 25, No. Supplement 1, P135, 2019, p. S173.

Research output: Contribution to journal › Meeting abstract › peer-review

TY - JOUR

T1 - Assessment of novel blood pressure corrected cardio-ankle vascular index in response to acute blood pressure changes

AU - Mestanik, Michal

AU - Spronck, Bart

AU - Jurko, Alexander

AU - Mestanikova, Andrea

AU - Jurko, Tomas

AU - Butlin, Mark

AU - Avolio, Alberto

AU - Olexova, Lucia Bona

AU - Visnovcova, Zuzana

AU - Sekaninova, Nikola

AU - Tonhajzerova, Ingrid

N1 - Copyright the Association for Research into Arterial Structure and Physiology 2019. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2019

Y1 - 2019

N2 - Background: Cardio-ankle vascular index (CAVI) has long been considered a measure of arterial stiffness independent of short-term changes in blood pressure (BP) [1]. Recently and theoretically, CAVI was found to be partially affected by actual BP, thus, a novel BP-corrected index, CAVI0, was proposed to diminish these effects [2,3]. Direct, repeated measures experimental data comparing CAVI’s and CAVI0’s acute blood pressure dependence is lacking. Hence, the aim of this study was to assess the effects of short-term changes of BP on CAVI0 in comparison with standard CAVI.Methods: 60 healthy adults were examined using vascular screening system VaSera 1500 N (Fukuda Denshi Co., Tokyo, Japan) during four examination periods lasting 5 minutes – baseline, cold pressor test (CPT), recovery period, and isometric handgrip exercise (IHE). CAVI and cardiovascular parameters for calculation of CAVI0 were measured after baseline, at the peak of pressor response to CPT, after recovery period, and at the peak of pressor response to IHE. CAVI, CAVI0, and mean BP were assessed for all periods.Results: CAVI significantly increased during CPT compared to baseline rest (p = 0.008), returned to baseline values during recovery period (p = 0.011 compared to CPT), and significantly increased during IHE compared to recovery period (p = 0.002). No significant changes of CAVI0 were found. CAVI significantly correlated with changes in mean BP (p = 0.012; multilevel regression); CAVI0 did not (p = 0.570).Conclusion: In this repeated measures, experimental, acute study, CAVI showed short-term blood pressure dependence, whereas CAVI0 did not.

AB - Background: Cardio-ankle vascular index (CAVI) has long been considered a measure of arterial stiffness independent of short-term changes in blood pressure (BP) [1]. Recently and theoretically, CAVI was found to be partially affected by actual BP, thus, a novel BP-corrected index, CAVI0, was proposed to diminish these effects [2,3]. Direct, repeated measures experimental data comparing CAVI’s and CAVI0’s acute blood pressure dependence is lacking. Hence, the aim of this study was to assess the effects of short-term changes of BP on CAVI0 in comparison with standard CAVI.Methods: 60 healthy adults were examined using vascular screening system VaSera 1500 N (Fukuda Denshi Co., Tokyo, Japan) during four examination periods lasting 5 minutes – baseline, cold pressor test (CPT), recovery period, and isometric handgrip exercise (IHE). CAVI and cardiovascular parameters for calculation of CAVI0 were measured after baseline, at the peak of pressor response to CPT, after recovery period, and at the peak of pressor response to IHE. CAVI, CAVI0, and mean BP were assessed for all periods.Results: CAVI significantly increased during CPT compared to baseline rest (p = 0.008), returned to baseline values during recovery period (p = 0.011 compared to CPT), and significantly increased during IHE compared to recovery period (p = 0.002). No significant changes of CAVI0 were found. CAVI significantly correlated with changes in mean BP (p = 0.012; multilevel regression); CAVI0 did not (p = 0.570).Conclusion: In this repeated measures, experimental, acute study, CAVI showed short-term blood pressure dependence, whereas CAVI0 did not.

U2 - 10.2991/artres.k.191224.158

DO - 10.2991/artres.k.191224.158

M3 - Meeting abstract

VL - 25

SP - S173

JO - Artery Research

JF - Artery Research

SN - 1872-9312

IS - Supplement 1

M1 - P135

T2 - Association for Research into Arterial Structure and Physiology Conference 2019

Y2 - 10 October 2019 through 12 October 2019

ER -