Association of dietary fiber and risk of hip fracture in men from the Framingham Osteoporosis Study and the Concord Health and Ageing in Men Project

Zhaoli Dai, Vasant Hirani, Shivani Sahni, David T. Felson, Vasi Naganathan, Fiona Blyth, David Le Couteur, David Handelsman, Markus J. Seibel, Louise Waite, Douglas P. Kiel, Robert Cumming

Research output: Contribution to journalArticlepeer-review

Abstract

Background:
Data in the Offspring Framingham Osteoporosis Study (FOS) suggested that higher intake of dietary fiber was modestly protective against loss of bone mineral density at the femoral neck in men but not in women.

Aim:
To examine the relationship of fiber intake with risk of hip fractures in men.

Methods:
We included 367 men from the FOS Original cohort, 1730 men from the FOS Offspring cohort, and 782 men from the Concord Health and Ageing in Men Project (CHAMP) in the analysis. Incident fractures were defined as medically confirmed first occurrence of osteoporotic fractures at the proximal femur. Fiber intake was estimated via a validated food frequency questionnaire (FFQ) or diet history. Cox proportional hazards models were applied to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). A random-effects model was used to estimate the pooled relative risk in meta-analysis.

Results:
Seventy-two incident hip fractures were identified, of which 24 occurred in the FOS Original cohort [mean (SD): age 75.3 (5.1) years; follow-up time: 8.5 (6.2) years; dietary fiber: 19 (8) (g/d)], 19 in the FOS Offspring cohort [58.8 (9.8) years; 11.0 (5.9) years; 19 (8) (g/d)], and 29 in CHAMP [81.4 (4.5) years; 5.2 (1.5) years; 28 (10) (g/d)]. We did not find significant associations within each cohort between fiber intake and risk of hip fractures. The pooled HR (95% CI) was 0.80 (0.39, 1.66) comparing energy-adjusted dietary fiber at tertile 3 vs. tertile 1 (I2 = 0, p = 0.56).

Conclusion:
These data suggested that dietary fiber was not associated with risk of incident hip fractures in men.
Original languageEnglish
JournalNutrition and Health
DOIs
Publication statusE-pub ahead of print - 4 May 2021

Keywords

  • dietary fiber
  • osteoporosis
  • hip fracture
  • men

Fingerprint

Dive into the research topics of 'Association of dietary fiber and risk of hip fracture in men from the Framingham Osteoporosis Study and the Concord Health and Ageing in Men Project'. Together they form a unique fingerprint.

Cite this