Association of gastro-oesophageal reflux and chronic rhinosinusitis: systematic review and meta-analysis

Stewart R. Leason*, Henry P. Barham, Gretchen Oakley, Janet Rimmer, John M. del Gaudio, Jenna M. Christensen, Raymond Sacks, Richard J. Harvey

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    40 Citations (Scopus)


    Introduction: Gastro-oesophageal reflux disease (GORD) has been implicated in the development of chronic rhinosinusitis (CRS). The association of GORD with CRS is systematically assessed from the medical literature. Methodology: Embase and MEDLINE were searched using a comprehensive strategy limited to English language and Human subjects. Any study with original data on the experimental, diagnostic, treatment or prognostic association of CRS with GORD was included. Studies without a control group, case reports and review articles were excluded. Results: The search returned 958 records, with an additional 10 found from bibliographic lists; this produced 32 studies. The included studies (n=32) consisted of studies reporting pathogenic factors (n=20), epidemiological association (n=8), prognostic interactions (n=3), and a combination of these outcomes (n=1). Potential pathogenic roles for GORD in CRS were supported; CRS subjects had greater prevalence of intranasal Helicobacter pylori and acid reflux than subjects without CRS. CRS is more prevalent in GORD sufferers than those without GORD. Evidence is conflicting for GORD as a factor in CRS treatment failure. Conclusion: The results support a significant association of GORD with CRS. Physicians should be cognizant of the potential for acid and non-acid reflux as a driving factor in CRS.

    Original languageEnglish
    Pages (from-to)3-16
    Number of pages14
    Issue number1
    Publication statusPublished - 2017
    EventAmerican Academy of Otolaryngology - Head and Neck Surgery (AAO-HNS) Annual Meeting - Dallas, United States
    Duration: 27 Sept 201530 Sept 2015


    • sinusitis
    • gastroesophageal reflux
    • Helicobacter pylori
    • review
    • meta-analysis


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