Association of gastro-oesophageal reflux and chronic rhinosinusitis: systematic review and meta-analysis

Stewart R. Leason; Henry P. Barham; Gretchen Oakley; Janet Rimmer; John M. del Gaudio; Jenna M. Christensen; Raymond Sacks; Richard J. Harvey

doi:10.4193/Rhino16.177

Association of gastro-oesophageal reflux and chronic rhinosinusitis: systematic review and meta-analysis

Stewart R. Leason^*, Henry P. Barham, Gretchen Oakley, Janet Rimmer, John M. del Gaudio, Jenna M. Christensen, Raymond Sacks, Richard J. Harvey

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

Introduction: Gastro-oesophageal reflux disease (GORD) has been implicated in the development of chronic rhinosinusitis (CRS). The association of GORD with CRS is systematically assessed from the medical literature. Methodology: Embase and MEDLINE were searched using a comprehensive strategy limited to English language and Human subjects. Any study with original data on the experimental, diagnostic, treatment or prognostic association of CRS with GORD was included. Studies without a control group, case reports and review articles were excluded. Results: The search returned 958 records, with an additional 10 found from bibliographic lists; this produced 32 studies. The included studies (n=32) consisted of studies reporting pathogenic factors (n=20), epidemiological association (n=8), prognostic interactions (n=3), and a combination of these outcomes (n=1). Potential pathogenic roles for GORD in CRS were supported; CRS subjects had greater prevalence of intranasal Helicobacter pylori and acid reflux than subjects without CRS. CRS is more prevalent in GORD sufferers than those without GORD. Evidence is conflicting for GORD as a factor in CRS treatment failure. Conclusion: The results support a significant association of GORD with CRS. Physicians should be cognizant of the potential for acid and non-acid reflux as a driving factor in CRS.

Original language	English
Pages (from-to)	3-16
Number of pages	14
Journal	Rhinology
Volume	55
Issue number	1
DOIs	https://doi.org/10.4193/Rhino16.177
Publication status	Published - 2017
Event	American Academy of Otolaryngology - Head and Neck Surgery (AAO-HNS) Annual Meeting - Dallas, United States Duration: 27 Sept 2015 → 30 Sept 2015

Keywords

sinusitis
gastroesophageal reflux
Helicobacter pylori
review
meta-analysis

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10.4193/Rhino16.177

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title = "Association of gastro-oesophageal reflux and chronic rhinosinusitis: systematic review and meta-analysis",

abstract = "Introduction: Gastro-oesophageal reflux disease (GORD) has been implicated in the development of chronic rhinosinusitis (CRS). The association of GORD with CRS is systematically assessed from the medical literature. Methodology: Embase and MEDLINE were searched using a comprehensive strategy limited to English language and Human subjects. Any study with original data on the experimental, diagnostic, treatment or prognostic association of CRS with GORD was included. Studies without a control group, case reports and review articles were excluded. Results: The search returned 958 records, with an additional 10 found from bibliographic lists; this produced 32 studies. The included studies (n=32) consisted of studies reporting pathogenic factors (n=20), epidemiological association (n=8), prognostic interactions (n=3), and a combination of these outcomes (n=1). Potential pathogenic roles for GORD in CRS were supported; CRS subjects had greater prevalence of intranasal Helicobacter pylori and acid reflux than subjects without CRS. CRS is more prevalent in GORD sufferers than those without GORD. Evidence is conflicting for GORD as a factor in CRS treatment failure. Conclusion: The results support a significant association of GORD with CRS. Physicians should be cognizant of the potential for acid and non-acid reflux as a driving factor in CRS.",

keywords = "sinusitis, gastroesophageal reflux, Helicobacter pylori, review, meta-analysis",

author = "Leason, {Stewart R.} and Barham, {Henry P.} and Gretchen Oakley and Janet Rimmer and {del Gaudio}, {John M.} and Christensen, {Jenna M.} and Raymond Sacks and Harvey, {Richard J.}",

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AU - Barham, Henry P.

AU - Oakley, Gretchen

AU - Rimmer, Janet

AU - del Gaudio, John M.

AU - Christensen, Jenna M.

AU - Sacks, Raymond

AU - Harvey, Richard J.

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AB - Introduction: Gastro-oesophageal reflux disease (GORD) has been implicated in the development of chronic rhinosinusitis (CRS). The association of GORD with CRS is systematically assessed from the medical literature. Methodology: Embase and MEDLINE were searched using a comprehensive strategy limited to English language and Human subjects. Any study with original data on the experimental, diagnostic, treatment or prognostic association of CRS with GORD was included. Studies without a control group, case reports and review articles were excluded. Results: The search returned 958 records, with an additional 10 found from bibliographic lists; this produced 32 studies. The included studies (n=32) consisted of studies reporting pathogenic factors (n=20), epidemiological association (n=8), prognostic interactions (n=3), and a combination of these outcomes (n=1). Potential pathogenic roles for GORD in CRS were supported; CRS subjects had greater prevalence of intranasal Helicobacter pylori and acid reflux than subjects without CRS. CRS is more prevalent in GORD sufferers than those without GORD. Evidence is conflicting for GORD as a factor in CRS treatment failure. Conclusion: The results support a significant association of GORD with CRS. Physicians should be cognizant of the potential for acid and non-acid reflux as a driving factor in CRS.

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KW - gastroesophageal reflux

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Association of gastro-oesophageal reflux and chronic rhinosinusitis: systematic review and meta-analysis

Abstract

Keywords

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