Association of haemodynamic indices of central and peripheral pressure with subclinical target organ damage

Junli Zuo, Shaoli Chu, Isabella Tan, Mark Butlin, Jiehui Zhao, Alberto Avolio

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background: Central aortic pressure has often been shown to be more closely associated with markers of vascular function and incidence of cardiovascular events compared to peripheral pressure. However, the potential clinical use of central aortic or peripheral haemodynamic indices as markers of target organ damage (TOD) has not been fully established. Methods: We evaluated associations of TOD with central aortic and peripheral haemodynamic indices (central aortic [cPP] and peripheral pulse pressure [pPP], central aortic augmentation index, and central and peripheral waveform factor) in 770 hospital inpatients (age 60 ± 10 years, 473 males) with primary hypertension. TOD was quantified in terms of arterial stiffness as measured by carotid-femoral pulse wave velocity (cfPWV), carotid intima-media thickness (IMT), and urine albumin-to-creatinine ratio (ACR). Subclinical TOD was defined as carotid IMT >0.9 mm, urine ACR >3.5 mg/mmol in females and >2.5 mg/mmol in males and/or cfPWV >12 m/s. Results: Both cPP and pPP showed significant correlation with cfPWV (r = 0.41 vs. 0.40; p <0.01), ACR (r = 0.24 vs. 0.27; p <0.01) and carotid IMT (r = 0.14 vs. 0.15; p <0.01). Each SD increase in pPP and cPP was associated with increased risk of cfPWV >12 m/s (odds ratio [OR] = 2.7 and 2.9 for pPP and cPP, respectively), ACR >2.5 mg/mmol (OR = 1.2 and 1.4, respectively), and carotid IMT >0.9 mm (OR = 1.46 and 1.53, respectively). Compared to pPP, cPP had higher predictive power for TOD for age >= 60 years (OR = 3.07, p <0.001). Conclusions: Although both pPP and cPP show an association with TOD in a hypertensive population, cPP provides additional information beyond pPP associated with TOD in a hypertensive cohort. Central aortic haemodynamic indices as potential biomarkers of subclinical TOD need to be validated by further prospective studies.

LanguageEnglish
Pages133-143
Number of pages11
JournalPulse (Basel, Switzerland)
Volume5
Issue number1-4
DOIs
Publication statusPublished - 2017

Keywords

  • Target organ damage
  • Carotid-femoral pulse wave velocity
  • Pulse wave analysis
  • Intima-media thickness
  • Albumin-to-creatinine ratio

Cite this

@article{717ed58d74ea4d389f757c5cf9fe57e5,
title = "Association of haemodynamic indices of central and peripheral pressure with subclinical target organ damage",
abstract = "Background: Central aortic pressure has often been shown to be more closely associated with markers of vascular function and incidence of cardiovascular events compared to peripheral pressure. However, the potential clinical use of central aortic or peripheral haemodynamic indices as markers of target organ damage (TOD) has not been fully established. Methods: We evaluated associations of TOD with central aortic and peripheral haemodynamic indices (central aortic [cPP] and peripheral pulse pressure [pPP], central aortic augmentation index, and central and peripheral waveform factor) in 770 hospital inpatients (age 60 ± 10 years, 473 males) with primary hypertension. TOD was quantified in terms of arterial stiffness as measured by carotid-femoral pulse wave velocity (cfPWV), carotid intima-media thickness (IMT), and urine albumin-to-creatinine ratio (ACR). Subclinical TOD was defined as carotid IMT >0.9 mm, urine ACR >3.5 mg/mmol in females and >2.5 mg/mmol in males and/or cfPWV >12 m/s. Results: Both cPP and pPP showed significant correlation with cfPWV (r = 0.41 vs. 0.40; p <0.01), ACR (r = 0.24 vs. 0.27; p <0.01) and carotid IMT (r = 0.14 vs. 0.15; p <0.01). Each SD increase in pPP and cPP was associated with increased risk of cfPWV >12 m/s (odds ratio [OR] = 2.7 and 2.9 for pPP and cPP, respectively), ACR >2.5 mg/mmol (OR = 1.2 and 1.4, respectively), and carotid IMT >0.9 mm (OR = 1.46 and 1.53, respectively). Compared to pPP, cPP had higher predictive power for TOD for age >= 60 years (OR = 3.07, p <0.001). Conclusions: Although both pPP and cPP show an association with TOD in a hypertensive population, cPP provides additional information beyond pPP associated with TOD in a hypertensive cohort. Central aortic haemodynamic indices as potential biomarkers of subclinical TOD need to be validated by further prospective studies.",
keywords = "Target organ damage, Carotid-femoral pulse wave velocity, Pulse wave analysis, Intima-media thickness, Albumin-to-creatinine ratio",
author = "Junli Zuo and Shaoli Chu and Isabella Tan and Mark Butlin and Jiehui Zhao and Alberto Avolio",
year = "2017",
doi = "10.1159/000484441",
language = "English",
volume = "5",
pages = "133--143",
journal = "Pulse (Basel, Switzerland)",
issn = "2235-8668",
publisher = "Karger",
number = "1-4",

}

Association of haemodynamic indices of central and peripheral pressure with subclinical target organ damage. / Zuo, Junli; Chu, Shaoli; Tan, Isabella; Butlin, Mark; Zhao, Jiehui; Avolio, Alberto.

In: Pulse (Basel, Switzerland), Vol. 5, No. 1-4, 2017, p. 133-143.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Association of haemodynamic indices of central and peripheral pressure with subclinical target organ damage

AU - Zuo, Junli

AU - Chu, Shaoli

AU - Tan, Isabella

AU - Butlin, Mark

AU - Zhao, Jiehui

AU - Avolio, Alberto

PY - 2017

Y1 - 2017

N2 - Background: Central aortic pressure has often been shown to be more closely associated with markers of vascular function and incidence of cardiovascular events compared to peripheral pressure. However, the potential clinical use of central aortic or peripheral haemodynamic indices as markers of target organ damage (TOD) has not been fully established. Methods: We evaluated associations of TOD with central aortic and peripheral haemodynamic indices (central aortic [cPP] and peripheral pulse pressure [pPP], central aortic augmentation index, and central and peripheral waveform factor) in 770 hospital inpatients (age 60 ± 10 years, 473 males) with primary hypertension. TOD was quantified in terms of arterial stiffness as measured by carotid-femoral pulse wave velocity (cfPWV), carotid intima-media thickness (IMT), and urine albumin-to-creatinine ratio (ACR). Subclinical TOD was defined as carotid IMT >0.9 mm, urine ACR >3.5 mg/mmol in females and >2.5 mg/mmol in males and/or cfPWV >12 m/s. Results: Both cPP and pPP showed significant correlation with cfPWV (r = 0.41 vs. 0.40; p <0.01), ACR (r = 0.24 vs. 0.27; p <0.01) and carotid IMT (r = 0.14 vs. 0.15; p <0.01). Each SD increase in pPP and cPP was associated with increased risk of cfPWV >12 m/s (odds ratio [OR] = 2.7 and 2.9 for pPP and cPP, respectively), ACR >2.5 mg/mmol (OR = 1.2 and 1.4, respectively), and carotid IMT >0.9 mm (OR = 1.46 and 1.53, respectively). Compared to pPP, cPP had higher predictive power for TOD for age >= 60 years (OR = 3.07, p <0.001). Conclusions: Although both pPP and cPP show an association with TOD in a hypertensive population, cPP provides additional information beyond pPP associated with TOD in a hypertensive cohort. Central aortic haemodynamic indices as potential biomarkers of subclinical TOD need to be validated by further prospective studies.

AB - Background: Central aortic pressure has often been shown to be more closely associated with markers of vascular function and incidence of cardiovascular events compared to peripheral pressure. However, the potential clinical use of central aortic or peripheral haemodynamic indices as markers of target organ damage (TOD) has not been fully established. Methods: We evaluated associations of TOD with central aortic and peripheral haemodynamic indices (central aortic [cPP] and peripheral pulse pressure [pPP], central aortic augmentation index, and central and peripheral waveform factor) in 770 hospital inpatients (age 60 ± 10 years, 473 males) with primary hypertension. TOD was quantified in terms of arterial stiffness as measured by carotid-femoral pulse wave velocity (cfPWV), carotid intima-media thickness (IMT), and urine albumin-to-creatinine ratio (ACR). Subclinical TOD was defined as carotid IMT >0.9 mm, urine ACR >3.5 mg/mmol in females and >2.5 mg/mmol in males and/or cfPWV >12 m/s. Results: Both cPP and pPP showed significant correlation with cfPWV (r = 0.41 vs. 0.40; p <0.01), ACR (r = 0.24 vs. 0.27; p <0.01) and carotid IMT (r = 0.14 vs. 0.15; p <0.01). Each SD increase in pPP and cPP was associated with increased risk of cfPWV >12 m/s (odds ratio [OR] = 2.7 and 2.9 for pPP and cPP, respectively), ACR >2.5 mg/mmol (OR = 1.2 and 1.4, respectively), and carotid IMT >0.9 mm (OR = 1.46 and 1.53, respectively). Compared to pPP, cPP had higher predictive power for TOD for age >= 60 years (OR = 3.07, p <0.001). Conclusions: Although both pPP and cPP show an association with TOD in a hypertensive population, cPP provides additional information beyond pPP associated with TOD in a hypertensive cohort. Central aortic haemodynamic indices as potential biomarkers of subclinical TOD need to be validated by further prospective studies.

KW - Target organ damage

KW - Carotid-femoral pulse wave velocity

KW - Pulse wave analysis

KW - Intima-media thickness

KW - Albumin-to-creatinine ratio

U2 - 10.1159/000484441

DO - 10.1159/000484441

M3 - Article

VL - 5

SP - 133

EP - 143

JO - Pulse (Basel, Switzerland)

T2 - Pulse (Basel, Switzerland)

JF - Pulse (Basel, Switzerland)

SN - 2235-8668

IS - 1-4

ER -