Association of the dat1 genotype with inattentive behavior is mediated by reading ability in a general population sample

Kim M. Cornish*, Robert Savage, Darren R. Hocking, Chris P. Hollis

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    9 Citations (Scopus)

    Abstract

    Attention deficit hyperactivity disorder (ADHD) and reading disability (RD) frequently co-occur in the child population and therefore raise the possibility of shared genetic etiology. We used a quantitative trait loci (QTL) approach to assess the involvement of the dopamine transporter (DAT1) gene polymorphism in mediating reading disability and poor attention in a general population sample of primary school children aged 6-11 years in the UK. The potential confounding effects of IQ and chronological age were also investigated. We found an independent association between the homozygous DAT1 10/10 repeat genotype and RD that was not accounted for by the level of ADHD symptoms. This finding suggests that the DAT1 gene polymorphism may influence a common neural mechanism underlying both reading acquisition and ADHD symptoms.

    Original languageEnglish
    Pages (from-to)453-458
    Number of pages6
    JournalBrain and Cognition
    Volume77
    Issue number3
    DOIs
    Publication statusPublished - Dec 2011

    Keywords

    • Adhd
    • Attention
    • DAT1
    • Genetic linkage
    • Quantitative trait loci
    • Reading disability

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