Association study on glutathione S-transferase omega 1 and 2 and familial ALS

Elsmarieke Van De Giessen, Isabella Fogh, Sumana Gopinath, Bradley Smith, Xun Hu, John Powell, Peter Andersen, Garth Nicholson, Ammar Al Chalabi, Christopher E. Shaw

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Glutathione S-transferase omega 1 and 2 (GSTO1 and 2) protect from oxidative stress, a possible pathogenic mechanism underlying the pathogenesis of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and Alzheimer's disease. Significant association of age of onset in Alzheimer's patients with GSTO1 and 2 had recently been identified, suggesting a possibly similar association with ALS. In this study 12 Hapmap tagged SNPs in GSTO1 and 2 were genotyped in 251 Caucasian British, Australian and Swedish familial ALS (FALS) cases. No association was found for age of onset and survival of FALS in the British and Australian patients. In the Swedish patients, association for age of onset was found with several SNPs (p = 0.003-0.048). These results suggest a possible effect of the GSTO1 and 2 locus on age of onset of FALS.

Original languageEnglish
Pages (from-to)81-84
Number of pages4
JournalAmyotrophic Lateral Sclerosis
Volume9
Issue number2
DOIs
Publication statusPublished - 2008
Externally publishedYes

Fingerprint Dive into the research topics of 'Association study on glutathione S-transferase omega 1 and 2 and familial ALS'. Together they form a unique fingerprint.

Cite this