TY - JOUR
T1 - Association study on glutathione S-transferase omega 1 and 2 and familial ALS
AU - Van De Giessen, Elsmarieke
AU - Fogh, Isabella
AU - Gopinath, Sumana
AU - Smith, Bradley
AU - Hu, Xun
AU - Powell, John
AU - Andersen, Peter
AU - Nicholson, Garth
AU - Chalabi, Ammar Al
AU - Shaw, Christopher E.
PY - 2008
Y1 - 2008
N2 - Glutathione S-transferase omega 1 and 2 (GSTO1 and 2) protect from oxidative stress, a possible pathogenic mechanism underlying the pathogenesis of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and Alzheimer's disease. Significant association of age of onset in Alzheimer's patients with GSTO1 and 2 had recently been identified, suggesting a possibly similar association with ALS. In this study 12 Hapmap tagged SNPs in GSTO1 and 2 were genotyped in 251 Caucasian British, Australian and Swedish familial ALS (FALS) cases. No association was found for age of onset and survival of FALS in the British and Australian patients. In the Swedish patients, association for age of onset was found with several SNPs (p = 0.003-0.048). These results suggest a possible effect of the GSTO1 and 2 locus on age of onset of FALS.
AB - Glutathione S-transferase omega 1 and 2 (GSTO1 and 2) protect from oxidative stress, a possible pathogenic mechanism underlying the pathogenesis of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and Alzheimer's disease. Significant association of age of onset in Alzheimer's patients with GSTO1 and 2 had recently been identified, suggesting a possibly similar association with ALS. In this study 12 Hapmap tagged SNPs in GSTO1 and 2 were genotyped in 251 Caucasian British, Australian and Swedish familial ALS (FALS) cases. No association was found for age of onset and survival of FALS in the British and Australian patients. In the Swedish patients, association for age of onset was found with several SNPs (p = 0.003-0.048). These results suggest a possible effect of the GSTO1 and 2 locus on age of onset of FALS.
UR - http://www.scopus.com/inward/record.url?scp=42549116323&partnerID=8YFLogxK
U2 - 10.1080/17482960701702553
DO - 10.1080/17482960701702553
M3 - Article
C2 - 18427999
AN - SCOPUS:42549116323
SN - 1748-2968
VL - 9
SP - 81
EP - 84
JO - Amyotrophic Lateral Sclerosis
JF - Amyotrophic Lateral Sclerosis
IS - 2
ER -