Associations between DNA methylation and telomere length during early life: insight from wild zebra finches (Taeniopygia guttata)

Elizabeth L. Sheldon*, Riccardo Ton, Winnie Boner, Pat Monaghan, Shirley Raveh, Aaron W. Schrey, Simon C. Griffith

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    10 Citations (Scopus)

    Abstract

    Telomere length and DNA methylation (DNAm) are two promising biomarkers of biological age. Environmental factors and life history traits are known to affect variation in both these biomarkers, especially during early life, yet surprisingly little is known about their reciprocal association, especially in natural populations. Here, we explore how variation in DNAm, growth rate, and early-life conditions are associated with telomere length changes during development. We tested these associations by collecting data from wild, nestling zebra finches in the Australian desert. We found that increases in the level of DNAm were negatively correlated with telomere length changes across early life. We also confirm previously documented effects of post hatch growth rate and clutch size on telomere length in a natural ecological context for a species that has been extensively studied in the laboratory. However, we did not detect any effect of ambient temperature during developmental on telomere length dynamics. We also found that the absolute telomere length of wild zebra finches, measured using the in-gel TRF method, was similar to that of captive birds. Our findings highlight exciting new opportunities to link and disentangle potential relationships between DNA based biomarkers of ageing, and of physiological reactions to environmental change.

    Original languageEnglish
    Pages (from-to)6261-6272
    Number of pages12
    JournalMolecular Ecology
    Volume31
    Issue number23
    Early online date5 Oct 2021
    DOIs
    Publication statusPublished - Dec 2022

    Keywords

    • ageing
    • Aves
    • biomarkers
    • development
    • life history
    • temperature effects

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