TY - JOUR
T1 - Associations between intake of dietary flavonoids and 10-year incidence of age-related hearing loss
AU - Gopinath, Bamini
AU - McMahon, Catherine M.
AU - Lewis, Joshua R.
AU - Bondonno, Nicola P.
AU - Bondonno, Catherine P.
AU - Burlutsky, George
AU - Hodgson, Jonathan M.
AU - Mitchell, Paul
N1 - Copyright the Author(s) 2020. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.
PY - 2020/11
Y1 - 2020/11
N2 - Dietary flavonoids are vasoactive phytochemicals with promising anti-inflammatory properties. We aimed to assess the associations between baseline intakes of six commonly consumed flavonoid subclasses and 10-year incidence of age-related hearing loss. At baseline, 1691 participants aged 50+ years had information on dietary intakes and hearing status. Hearing loss was defined as the pure-tone average of frequencies 0.5, 1.0, 2.0, and 4.0 kHz > 25 dB hearing level (HL). Dietary data were collected through a semi-quantitative food frequency questionnaire. The flavonoid content of foods was estimated using US databases. During the 10-year follow-up, 260 (31.6%) new cases of hearing loss (incident) were observed. After multivariable adjustment, participants in the fourth versus first quartile (reference group) of intake of dietary isoflavone had 36% lower risk of incident hearing loss after 10 years: odds ratios (OR) 0.64 (95% confidence intervals, CI, 0.42–0.99); p-value for trend = 0.03. Nonsignificant associations were observed between the other five flavonoid subclasses and 10-year incidence of hearing loss. Our findings do not support the hypothesis that the intake of dietary flavonoids protect against long-term risk of hearing loss. The association with isoflavone intake needs to be confirmed by other population-based studies.
AB - Dietary flavonoids are vasoactive phytochemicals with promising anti-inflammatory properties. We aimed to assess the associations between baseline intakes of six commonly consumed flavonoid subclasses and 10-year incidence of age-related hearing loss. At baseline, 1691 participants aged 50+ years had information on dietary intakes and hearing status. Hearing loss was defined as the pure-tone average of frequencies 0.5, 1.0, 2.0, and 4.0 kHz > 25 dB hearing level (HL). Dietary data were collected through a semi-quantitative food frequency questionnaire. The flavonoid content of foods was estimated using US databases. During the 10-year follow-up, 260 (31.6%) new cases of hearing loss (incident) were observed. After multivariable adjustment, participants in the fourth versus first quartile (reference group) of intake of dietary isoflavone had 36% lower risk of incident hearing loss after 10 years: odds ratios (OR) 0.64 (95% confidence intervals, CI, 0.42–0.99); p-value for trend = 0.03. Nonsignificant associations were observed between the other five flavonoid subclasses and 10-year incidence of hearing loss. Our findings do not support the hypothesis that the intake of dietary flavonoids protect against long-term risk of hearing loss. The association with isoflavone intake needs to be confirmed by other population-based studies.
KW - age-related hearing loss
KW - Blue Mountains Hearing Study
KW - flavonoids
KW - isoflavone
KW - incidence
UR - http://www.scopus.com/inward/record.url?scp=85094601176&partnerID=8YFLogxK
UR - http://purl.org/au-research/grants/nhmrc/974159
UR - http://purl.org/au-research/grants/nhmrc/991407
UR - http://purl.org/au-research/grants/nhmrc/211069
UR - http://purl.org/au-research/grants/nhmrc/262120
U2 - 10.3390/nu12113297
DO - 10.3390/nu12113297
M3 - Article
C2 - 33126490
AN - SCOPUS:85094601176
SN - 2072-6643
VL - 12
SP - 1
EP - 8
JO - Nutrients
JF - Nutrients
IS - 11
M1 - 3297
ER -