TY - JOUR
T1 - Associations between vitamin D receptor gene polymorphisms and osteoarthritis
T2 - an updated meta-analysis
AU - Zhu, Zhao-Hua
AU - Jin, Xing-Zhong
AU - Zhang, Weiya
AU - Chen, Mao
AU - Ye, Dong-Qing
AU - Zhai, Yu
AU - Dong, Fu-Long
AU - Shen, Cai-Liang
AU - Ding, Changhai
PY - 2014
Y1 - 2014
N2 - Objective: Vitamin D receptor (VDR) gene polymorphisms may be associated with the risk of OA, however, evidence for this is controversial. This meta-analysis aims to confirm whether VDR gene polymorphisms are associated with OA.
Methods: Meta-analyses on the association between OA and VDR ApaI, BsmI, TaqI and FokI polymorphisms were conducted using allele and homozygote contrast and contrasts in the recessive and dominant models. Stratification analyses by different demographic regions (Europe vs Asian) were also performed and pooled odds ratios (ORs) were obtained using the random effects model if the results were heterogeneous.
Results: A total of 13 relevant studies involving OA patients (n = 2104) and controls (n = 2939) were included in the analysis. There were significant associations between VDR ApaI polymorphisms and OA in the Asian population (A vs a: OR= 1.16, 95% CI 1.02, 1.32, P = 0.025; AA vs Aa/aa: OR= 1.36, 95% CI 1.04, 1.77, P = 0.025; AA vs aa: OR= 1.35, 95% CI 1.00, 1.80, P = 0.047), but not in the whole population. There was also a statistically significant association between FokI polymorphism and OA (FF vs Ff/ff: OR= 0.65, 95% CI 0.44, 0.95, P = 0.024); however, this result was derived from only two studies. No significant associations were found between VDR TaqI and BsmI polymorphisms and OA.
Conclusion: There are modest but statistically significant associations between VDR ApaI polymorphisms and the susceptibility of OA in the Asian population.
AB - Objective: Vitamin D receptor (VDR) gene polymorphisms may be associated with the risk of OA, however, evidence for this is controversial. This meta-analysis aims to confirm whether VDR gene polymorphisms are associated with OA.
Methods: Meta-analyses on the association between OA and VDR ApaI, BsmI, TaqI and FokI polymorphisms were conducted using allele and homozygote contrast and contrasts in the recessive and dominant models. Stratification analyses by different demographic regions (Europe vs Asian) were also performed and pooled odds ratios (ORs) were obtained using the random effects model if the results were heterogeneous.
Results: A total of 13 relevant studies involving OA patients (n = 2104) and controls (n = 2939) were included in the analysis. There were significant associations between VDR ApaI polymorphisms and OA in the Asian population (A vs a: OR= 1.16, 95% CI 1.02, 1.32, P = 0.025; AA vs Aa/aa: OR= 1.36, 95% CI 1.04, 1.77, P = 0.025; AA vs aa: OR= 1.35, 95% CI 1.00, 1.80, P = 0.047), but not in the whole population. There was also a statistically significant association between FokI polymorphism and OA (FF vs Ff/ff: OR= 0.65, 95% CI 0.44, 0.95, P = 0.024); however, this result was derived from only two studies. No significant associations were found between VDR TaqI and BsmI polymorphisms and OA.
Conclusion: There are modest but statistically significant associations between VDR ApaI polymorphisms and the susceptibility of OA in the Asian population.
KW - vitamin D receptor
KW - osteoarthritis
KW - polymorphisms
KW - meta-analysis
UR - http://www.scopus.com/inward/record.url?scp=84900792987&partnerID=8YFLogxK
U2 - 10.1093/rheumatology/ket418
DO - 10.1093/rheumatology/ket418
M3 - Article
C2 - 24497541
VL - 53
SP - 998
EP - 1008
JO - Rheumatology
JF - Rheumatology
SN - 1462-0324
IS - 6
ER -