TY - JOUR
T1 - Associations of Non-Hodgkin Lymphoma (NHL) risk with autoimmune conditions according to putative NHL loci
AU - Wang, Sophia S.
AU - Vajdic, Claire M.
AU - Linet, Martha S.
AU - Slager, Susan L.
AU - Voutsinas, Jenna
AU - Nieters, Alexandra
AU - De Sanjose, Silvia
AU - Cozen, Wendy
AU - Alarcón, Graciela S.
AU - Martinez-Maza, Otoniel
AU - Brown, Elizabeth E.
AU - Bracci, Paige M.
AU - Lightfoot, Tracy
AU - Turner, Jennifer
AU - Hjalgrim, Henrik
AU - Spinelli, John J.
AU - Zheng, Tongzhang
AU - Morton, Lindsay M.
AU - Birmann, Brenda M.
AU - Flowers, Christopher R.
AU - Paltiel, Ora
AU - Becker, Nikolaus
AU - Holly, Elizabeth A.
AU - Kane, Eleanor
AU - Weisenburger, Dennis
AU - Maynadie, Marc
AU - Cocco, Pierluigi
AU - Foretova, Lenka
AU - Staines, Anthony
AU - Davis, Scott
AU - Severson, Richard
AU - Cerhan, James R.
AU - Breen, Elizabeth C.
AU - Lan, Qing
AU - Brooks-Wilson, Angela
AU - De Roos, Anneclaire J.
AU - Smith, Martyn T.
AU - Roman, Eve
AU - Boffetta, Paolo
AU - Kricker, Anne
AU - Zhang, Yawei
AU - Skibola, Christine
AU - Chanock, Stephen J.
AU - Rothman, Nathaniel
AU - Benavente, Yolanda
AU - Hartge, Patricia
AU - Smedby, Karin E.
PY - 2015/12/8
Y1 - 2015/12/8
N2 - Autoimmune conditions and immune system-related genetic variations are associated with risk of non-Hodgkin lymphoma (NHL). In a pooled analysis of 8,692 NHL cases and 9,260 controls from 14 studies (1988-2007) within the International Lymphoma Epidemiology Consortium, we evaluated the interaction between immune system genetic variants and autoimmune conditions in NHL risk. We evaluated the immunity-related single nucleotide polymorphisms rs1800629 (tumor necrosis factor gene (TNF) G308A), rs1800890 (interleukin-10 gene (IL10) T3575A), rs6457327 (human leukocyte antigen gene (HLA) class I), rs10484561 (HLA class II), and rs2647012 (HLA class II)) and categorized autoimmune conditions as primarily mediated by B-cell or T-cell responses. We constructed unconditional logistic regression models to measure associations between autoimmune conditions and NHL with stratification by genotype. Autoimmune conditions mediated by B-cell responses were associated with increased NHL risk, specifically diffuse large B-cell lymphoma (odds ratio (OR) = 3.11, 95% confidence interval (CI): 2.25, 4.30) and marginal zone lymphoma (OR = 5.80, 95% CI: 3.82, 8.80); those mediated by T-cell responses were associated with peripheral T-cell lymphoma (OR = 2.14, 95% CI: 1.35, 3.38). In the presence of the rs1800629 AG/AA genotype, B-cell-mediated autoimmune conditions increased NHL risk (OR = 3.27, 95% CI: 2.07, 5.16; P-interaction = 0.03) in comparison with the GG genotype (OR = 1.82, 95% CI: 1.31, 2.53). This interaction was consistent across major B-cell NHL subtypes, including marginal zone lymphoma (P-interaction = 0.02) and follicular lymphoma (P-interaction = 0.04).
AB - Autoimmune conditions and immune system-related genetic variations are associated with risk of non-Hodgkin lymphoma (NHL). In a pooled analysis of 8,692 NHL cases and 9,260 controls from 14 studies (1988-2007) within the International Lymphoma Epidemiology Consortium, we evaluated the interaction between immune system genetic variants and autoimmune conditions in NHL risk. We evaluated the immunity-related single nucleotide polymorphisms rs1800629 (tumor necrosis factor gene (TNF) G308A), rs1800890 (interleukin-10 gene (IL10) T3575A), rs6457327 (human leukocyte antigen gene (HLA) class I), rs10484561 (HLA class II), and rs2647012 (HLA class II)) and categorized autoimmune conditions as primarily mediated by B-cell or T-cell responses. We constructed unconditional logistic regression models to measure associations between autoimmune conditions and NHL with stratification by genotype. Autoimmune conditions mediated by B-cell responses were associated with increased NHL risk, specifically diffuse large B-cell lymphoma (odds ratio (OR) = 3.11, 95% confidence interval (CI): 2.25, 4.30) and marginal zone lymphoma (OR = 5.80, 95% CI: 3.82, 8.80); those mediated by T-cell responses were associated with peripheral T-cell lymphoma (OR = 2.14, 95% CI: 1.35, 3.38). In the presence of the rs1800629 AG/AA genotype, B-cell-mediated autoimmune conditions increased NHL risk (OR = 3.27, 95% CI: 2.07, 5.16; P-interaction = 0.03) in comparison with the GG genotype (OR = 1.82, 95% CI: 1.31, 2.53). This interaction was consistent across major B-cell NHL subtypes, including marginal zone lymphoma (P-interaction = 0.02) and follicular lymphoma (P-interaction = 0.04).
UR - http://www.scopus.com/inward/record.url?scp=84924405081&partnerID=8YFLogxK
U2 - 10.1093/aje/kwu290
DO - 10.1093/aje/kwu290
M3 - Article
C2 - 25713336
AN - SCOPUS:84924405081
SN - 0002-9262
VL - 181
SP - 406
EP - 421
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
IS - 6
ER -