Astrocytes et infection lentivirale dans le modèle expérimental du macaque infecté par le SIVmac251

Translated title of the contribution: Astrocytes and lentivirus infection in an experimental models of macaque infected with SIVmac251

G. Guillemin*, J. Croitoru, F. D. Boussin, R. Le Grand, M. Franck-Duchenne, D. Dormont

*Corresponding author for this work

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The present study demonstrates the susceptibility of astrocytes to infection with SIVmac251. Indeed, primary cultures of astrocytes derived from simian adult brains, can be infected in vitro with the SIVmac251. Results show that SIVmac251 establishes a persistent infection in primary astroglial cultures and that viral replication can be reactivated by TNF-alpha, GM-CSF, IFN-gamma. Viral proteins as Nef, Rev, Vpx and occasionally gp120/160 are evidenced by immunocytochemistry. In vivo SIVmac251 and/or HIV-2 infected astrocytes have been isolated from brains of macaques following ex vivo primary cultures. The whole of these results demonstrated that, in this model, SIV establishes a persistent state of infection of astrocytes, that viral replication can be reactivated by cytokines and moreover suggest strongly an in vivo infection of astrocytes in the brain of these infected macaques.

Original languageFrench
Pages (from-to)179-186
Number of pages8
JournalComptes rendus des séances de la Société de biologie et de ses filiales
Volume192
Issue number1
Publication statusPublished - 1998
Externally publishedYes

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