Augmentation of Sympathetic Venoconstriction by Angiotensin II in Human Dorsal Hand Veins

D. J. Webb, N. Benjamin, J. R. Cockcroft, J. G. Collier

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7 Citations (Scopus)

Abstract

The constriction produced by a single deep breath was measured simultaneously in two adjacent hand veins in normal subjects. One vein was infused with saline or angiotensin II; the other acted as a control. A dose of angiotensin II (1 pmol/min) that did produce venous constriction directly significantly augmented the constriction caused by deep breath in eight subjects (P `.01). In a further six subjects the same dose had no effect on venoconstriction caused by infused noradrenaline. We conclude that angiotensin II causes venoconstriction indirectly by augmenting sympathetically mediated responses, possibly by a presynaptic mechanism. Am J Hypertens 1989;2:721–723.

Original languageEnglish
Pages (from-to)721-723
Number of pages3
JournalAmerican Journal of Hypertension
Volume2
Issue number9
DOIs
Publication statusPublished - 1989

Keywords

  • Angiotensin II
  • Sympathetic nervous system
  • Veins

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