Autoantibodies directed to centromere protein F in a patient with BRCA1 gene mutation

Fiona Moghaddas*, Fredrick Joshua, Roberta Taylor, Marvin J. Fritzler, Ban Hock Toh

*Corresponding author for this work

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Background: Autoantibodies directed to centromere protein F were first reported in 1993 and their association with malignancy has been well documented. Case: We present the case of a 48-year-old Caucasian female with a BRCA1 gene mutation associated with bilateral breast cancer. Antinuclear autoantibody immunofluorescence performed for workup of possible inflammatory arthropathy showed a high titre cell cycle related nuclear speckled pattern, with subsequent confirmation by addressable laser bead immunoassay of the target antigen as an immunodominant epitope at the C-terminus of centromere protein F. Conclusion: Here we review the current literature on centromere protein F, its association with breast cancer and present the first case of this antibody being identified in a person with a BRCA1 gene mutation.

Original languageEnglish
Article number84
Pages (from-to)1-4
Number of pages4
JournalBMC Research Notes
Publication statusPublished - 11 Feb 2016
Externally publishedYes

Bibliographical note

Copyright the Author(s) 2016. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.


  • antinuclear antibody
  • BRCA1
  • CENP-F
  • malignancy


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